biostudies-literatureHaghayegh SNIH grants UM1 CA186107, P01 CA87969, and U01 CA176726. NIH grants R01 OH009803 and R01 HD101101 to Eva Schernhammer. Yin Zhang was supported by Irene M. & Fredrick J. Stare Nutrition Education Fund Doctoral Scholarship and Mayer Fund Doctoral Scholarship2202https://www.ebi.ac.uk/biostudies/studies/S-EPMC9915636biostudies-literatureUnknown20(3)Bladder cancer is the sixth most common cancer in the United States. Night shift work has previously been linked with cancer risk. Whether there is an association between rotating night shift work and bladder cancer in women has not been studied previously. Eligible participants in the Nurses' Health Study (NHS, n = 82,147, 1988-2016) and Nurses' Health Study II (NHSII, n = 113,630, 1989-2015) were prospectively followed and a total of 620 and 122 incident bladder cancer cases were documented during the follow-up of NHS and NHSII, respectively. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for bladder cancer incidence. We observed a significantly increased risk of bladder cancer among women with >5 years of night shift work hInternational journal of environmental research and public healthRotating Night Shift Work and Bladder Cancer Risk in Women: Results of Two Prospective Cohort Studies.PMC9915636NIH grants UM1 CA186107, P01 CA87969, and U01 CA176726. NIH grants R01 OH009803 and R01 HD101101 to Eva Schernhammer. Yin Zhang was supported by Irene M. & Fredrick J. Stare Nutrition Education Fund Doctoral Scholarship and Mayer Fund Doctoral ScholarshipLiu YStrohmaier SMarkt SZhang YHaghayegh SSchernhammer EPapantoniou KGiovannucci EfalseRotating Night Shift Work and Bladder Cancer Risk in Women: Results of Two Prospective Cohort Studies.Bladder cancer is the sixth most common cancer in the United States. Night shift work has previously been linked with cancer risk. Whether there is an association between rotating night shift work and bladder cancer in women has not been studied previously. Eligible participants in the Nurses' Health Study (NHS, n = 82,147, 1988-2016) and Nurses' Health Study II (NHSII, n = 113,630, 1989-2015) were prospectively followed and a total of 620 and 122 incident bladder cancer cases were documented during the follow-up of NHS and NHSII, respectively. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for bladder cancer incidence. We observed a significantly increased risk of bladder cancer among women with >5 years of night shift work h2023-01-01T00:00:00Z2023 Jan2025-04-25T19:17:18.066Z2025-04-06T07:57:29.489ZS-EPMC99156363676757210.3390/ijerph20032202