{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Lanjewar AL"],"funding":["NIMH NIH HHS"],"pubmed_abstract":["Cognitive impairment is a common phenotype of neurodevelopmental disorders, but how these deficits arise remains elusive. Determining the onset of discrete cognitive capabilities facilitates studies in probing mechanisms underlying their emergence. The present study analyzed the emergence of contextual fear memory persistence (7-day memory retention) and remote memory (30-day memory retention). There was a rapid transition from postnatal day (P) 20 to P21, in which memory persistence emerged in C57Bl/6J male and female mice. Remote memory was present at P23, but expression was not robust compared to pubertal and adult mice. Previous studies reported that following deletion of the MET receptor tyrosine kinase (MET), there are fear memory deficits in adult mice and the timing of critical per"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.02.03.527024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9915741"],"repository":["biostudies-literature"],"pubmed_title":["Developmental and molecular contributions to contextual fear memory emergence in mice."],"pmcid":["PMC9915741"],"funding_grant_id":["R01 MH067842"],"pubmed_authors":["Eagleson KL","Levitt P","Lanjewar AL"],"additional_accession":[]},"is_claimable":false,"name":"Developmental and molecular contributions to contextual fear memory emergence in mice.","description":"Cognitive impairment is a common phenotype of neurodevelopmental disorders, but how these deficits arise remains elusive. Determining the onset of discrete cognitive capabilities facilitates studies in probing mechanisms underlying their emergence. The present study analyzed the emergence of contextual fear memory persistence (7-day memory retention) and remote memory (30-day memory retention). There was a rapid transition from postnatal day (P) 20 to P21, in which memory persistence emerged in C57Bl/6J male and female mice. Remote memory was present at P23, but expression was not robust compared to pubertal and adult mice. Previous studies reported that following deletion of the MET receptor tyrosine kinase (MET), there are fear memory deficits in adult mice and the timing of critical per","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-04-08T13:06:09.081Z","creation":"2025-04-05T11:27:27.488Z"},"accession":"S-EPMC9915741","cross_references":{"pubmed":["36778231"],"doi":["10.1101/2023.02.03.527024"]}}