biostudies-literatureYuan D2022 scientific research project of Sichuan Center for Disease Control and PreventionSichuan Science and Technology programScience and Technology Project of Sichuan Provincial Health CommitteeNational Natural Science Foundation of China2523https://www.ebi.ac.uk/biostudies/studies/S-EPMC9915990biostudies-literatureUnknown20(3)<h4>Objective</h4>The objective of this study was to understand the molecular transmission characteristics of newly reported HIV infections in the city of Pengzhou, Sichuan Province, to analyze the risk factors of transmission network and spatial clustering and the transmission characteristics, and to provide a scientific basis for precision prevention and intervention.<h4>Methods</h4>Anticoagulated whole blood was collected from newly reported HIV infections in Pengzhou from March 2019 to August 2021. After the plasma was isolated, the HIV-1 pol gene was amplified and sequenced by reverse transcriptase polymerase chain reaction (PCR). The obtained gene sequences were used to construct a maximum likelihood phylogenetic tree for the analysis of virus subtypes, and a molecular transmission nInternational journal of environmental research and public healthMolecular Transmission Network of Newly Reported HIV Infections in Pengzhou, Sichuan Province: A Study Based on Genomics and Spatial Epidemiology.PMC991599020PJ1212022NSFSC1547, 2020YJ0449zx202201, zx202101281803300Yuan DLiang SLi HLiu YLi YYang YZhong XZhang LHe QLi LLi NfalseMolecular Transmission Network of Newly Reported HIV Infections in Pengzhou, Sichuan Province: A Study Based on Genomics and Spatial Epidemiology.<h4>Objective</h4>The objective of this study was to understand the molecular transmission characteristics of newly reported HIV infections in the city of Pengzhou, Sichuan Province, to analyze the risk factors of transmission network and spatial clustering and the transmission characteristics, and to provide a scientific basis for precision prevention and intervention.<h4>Methods</h4>Anticoagulated whole blood was collected from newly reported HIV infections in Pengzhou from March 2019 to August 2021. After the plasma was isolated, the HIV-1 pol gene was amplified and sequenced by reverse transcriptase polymerase chain reaction (PCR). The obtained gene sequences were used to construct a maximum likelihood phylogenetic tree for the analysis of virus subtypes, and a molecular transmission n2023-01-01T00:00:00Z2023 Jan2025-04-25T19:22:27.235Z2024-10-18T03:15:55.066ZS-EPMC99159903676788910.3390/ijerph20032523