{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tabah A"],"funding":["Redcliffe Hospital Private Practice Trust Fund","European Society of Intensive Care Medicine","Medical Research Council","Norva Dahlia foundation","European Society of Clinical Microbiology and Infectious Diseases"],"pagination":["178-190"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9916499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(2)"],"pubmed_abstract":["<h4>Purpose</h4>In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials.<h4>Methods</h4>We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021.<h4>Results</h4>2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominant"],"journal":["Intensive care medicine"],"pubmed_title":["Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study."],"pmcid":["PMC9916499"],"funding_grant_id":["MR/V006118/1"],"pubmed_authors":["Brewster D","Sligl W","Duburcq T","Dabiri G","Montini LM","Alves M","Hasan RSB","Takaki S","Paskalis H","Batirel A","Kouroulas V","Lennard J","Kiani A","Patrier J","Leone M","Aldhalia A","Tomas ED","Pasieka B","Battaglini D","Georgopoulou M","Abidi K","Ouhadian M","Banach D","Xu L","Abilama F","Moorthi PD","Timsit JF","Sridharan DD","Layos N","Imzi N","Quesada MD","De Waele J","Elrabi O","Ceyhun S","Makino J","Povoa P","Saito H","De Waele E","Young M","Ramanan M","Sungurtekin H","Auchabie J","Marques AJP","Svensson CJ","Custovic A","Tinaslanidis G","Altin N","Pietraszek-Grzywaczewska I","Yamasaki M","Attwood B","Hewer T","Alfandari 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bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.","description":"<h4>Purpose</h4>In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials.<h4>Methods</h4>We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021.<h4>Results</h4>2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominant","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T19:02:07.128Z","creation":"2025-02-19T00:14:28.344Z"},"accession":"S-EPMC9916499","cross_references":{"pubmed":["36764959"],"doi":["10.1007/s00134-022-06944-2"]}}