biostudies-literatureTabah ARedcliffe Hospital Private Practice Trust FundEuropean Society of Intensive Care MedicineMedical Research CouncilNorva Dahlia foundationEuropean Society of Clinical Microbiology and Infectious Diseases178-190https://www.ebi.ac.uk/biostudies/studies/S-EPMC9916499biostudies-literatureUnknown49(2)<h4>Purpose</h4>In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials.<h4>Methods</h4>We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021.<h4>Results</h4>2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). 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JSzczesniak AYin CErsoy YDimopoulos GDe Schryver NSaber AMehtap SOzair ASarshad HZhang MTajvidi RMarchalot ADuarte TNoel CJakob SVasileiou MAqeelah AWongsurakiat PWajdi MAFernandez RPapathanakos GChukina MRegli ABortolotti PAzman AHSari AOzturk BOlatosi JOBaghbanian RBourenne JAlmiroudi MPBassetti MAsensio DMSokhan AErdogan CCastillo RARoger CMcguigan PMukherjee SAhmadi FZand FCartoze NCowton AStaiquly QBhadange NSavaie MValeanu LFong KKAkyol APetros SGeng NUgwu EMSudhirchandra SRosman JHaney MDe Bus LSanchez-Hurtado LLim JYSaracoglu KTTabatabaei SMNGratarola AVargas JPelagalli LVisvalingam SPrazak JPersec JMacfie CQian CRigler MFartoukh MZhou SAthanasa ZMarcu AShekhar SBaronia AYeh YCAhmed AKCarelli SEfthymiou ASoar NMateu PShigemitsu HQin BMarouli DHdada AKSzakmany TAslan ATJavaherforoosh FGuimaraes NNikolaou CKaimakamis EMckee RLe Meur AMarmanidou KHuang MAltintas NDFujitani SWang HWang JJobran RGuzeldag SHaibo QHerrera MOGZuccaro FWang RAparicio DMRoig RTamowicz BZormpa AYakubu SYKampolis CWang YAkbas TSerck NGarcon PSerghini IGoksu SGraham CHollevoet INg LXLEUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and the OUTCOMEREA NetworkPark SPerez-Nieto ORCerman JChikungwa MOladimeji MDavalos-Alvarez ADaroui IHssain AAKocagoz SBaby SKSakagianni ACotoia AHasan HBIasonidou CSchlevenin MGMisset BBroda HChandran JMetz CBaykam NNAntrolikar SZlojutro BNimbolkar JTempleton MAlsisi AKato HAlmiqlash BAyestaran JIRocca RFCakmak RNissar SLoftus SSabetian GDiab AMcCoshen LPeije LMasjedi MNg KJanny SWalid HAMIMendes ACSaidahmed EBotelho IKarmakar SNikolic MRenuka MKThomas-Rueddel DAksoy FKalfon PAlonzo MIRoshdy AKannan SHousni BElmandouh OSakkalis AAguilar CGMugazov MfalseEpidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.<h4>Purpose</h4>In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials.<h4>Methods</h4>We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021.<h4>Results</h4>2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominant2023-01-01T00:00:00Z2023 Feb2026-05-28T19:02:07.128Z2025-02-19T00:14:28.344ZS-EPMC99164993676495910.1007/s00134-022-06944-2