{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["An D"],"funding":["China Postdoctoral Science Foundation","National Natural Science Foundation of China"],"pagination":["2147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9916613"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(3)"],"pubmed_abstract":["Fluorescent chemosensors are powerful imaging tools used in a broad range of biomedical fields. However, the application of fluorescent dyes in bioimaging still remains challenging, with small Stokes shifts, interfering signals, background noise, and self-quenching on current microscope configurations. In this work, we reported a supramolecular cage (<b>C<sub>A</sub></b>) by coordination-driven self-assembly of benzothiadiazole derivatives and Eu(OTf)<sub>3</sub>. The <b>C<sub>A</sub></b> exhibited high fluorescence with a quantum yield (QY) of 38.57%, good photoluminescence (PL) stability, and a large Stokes shift (153 nm). Furthermore, the CCK-8 assay against U87 glioblastoma cells verified the low cytotoxicity of <b>C<sub>A</sub></b>. We revealed that the designed probes could be used as U87 cells targeting bioimaging."],"journal":["International journal of molecular sciences"],"pubmed_title":["Tailored Supramolecular Cage for Efficient Bio-Labeling."],"pmcid":["PMC9916613"],"funding_grant_id":["2021M692905","22101267, 21803059, U1904212, and U2004191"],"pubmed_authors":["Zhang HY","Shi L","Song MP","Li T","Hao XQ","Chen Y","An D"],"additional_accession":[]},"is_claimable":false,"name":"Tailored Supramolecular Cage for Efficient Bio-Labeling.","description":"Fluorescent chemosensors are powerful imaging tools used in a broad range of biomedical fields. However, the application of fluorescent dyes in bioimaging still remains challenging, with small Stokes shifts, interfering signals, background noise, and self-quenching on current microscope configurations. In this work, we reported a supramolecular cage (<b>C<sub>A</sub></b>) by coordination-driven self-assembly of benzothiadiazole derivatives and Eu(OTf)<sub>3</sub>. The <b>C<sub>A</sub></b> exhibited high fluorescence with a quantum yield (QY) of 38.57%, good photoluminescence (PL) stability, and a large Stokes shift (153 nm). Furthermore, the CCK-8 assay against U87 glioblastoma cells verified the low cytotoxicity of <b>C<sub>A</sub></b>. We revealed that the designed probes could be used as U87 cells targeting bioimaging.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-25T19:21:33.393Z","creation":"2025-04-06T07:58:39.323Z"},"accession":"S-EPMC9916613","cross_references":{"pubmed":["36768471"],"doi":["10.3390/ijms24032147"]}}