biostudies-literatureKlid SInstituto de Salud Carlos IIISpanish Ministry of Science and InnovationMiguel Servet tenure-track programAgency for Administration of University and ResearchCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas2486https://www.ebi.ac.uk/biostudies/studies/S-EPMC9917010biostudies-literatureUnknown24(3)Dyslipidemia in gestational diabetes has been associated with worse perinatal outcomes. The ANGPTL3-4-8 axis regulates lipid metabolism, especially in the transition from fasting to feeding. In this study, we evaluated the response of ANGPTL3, 4, and 8 after the intake of a mixed meal in women with normal glucose tolerance and gestational diabetes, and we assessed their gene expressions in different placental locations. Regarding the circulating levels of ANGPTL3, 4, and 8, we observed an absence of ANGPTL4 response after the intake of the meal in the GDM group compared to its presence in the control group. At the placental level, we observed a glucose tolerance-dependent expression pattern of <i>ANGPTL3</i> between the two placental sides. When we compared the GDM pregnancies with the conInternational journal of molecular sciencesThe ANGPTL3-4-8 Axis in Normal Gestation and in Gestational Diabetes, and Its Potential Involvement in Fetal Growth.PMC9917010RTI2018-093919-B-100CB07708/00122020FI_B 00980PID2021-122480OB-100PI 18/00516PI 20/00338PI 15/01562CPII16/00008CP10/00438PI 21/01479Jareno CKlid SAlgaba-Chueca FIngles-Puig MVendrell JMaymo-Masip EFernandez-Veledo SMadeira ABallesteros MGuarque AMegia AfalseThe ANGPTL3-4-8 Axis in Normal Gestation and in Gestational Diabetes, and Its Potential Involvement in Fetal Growth.Dyslipidemia in gestational diabetes has been associated with worse perinatal outcomes. The ANGPTL3-4-8 axis regulates lipid metabolism, especially in the transition from fasting to feeding. In this study, we evaluated the response of ANGPTL3, 4, and 8 after the intake of a mixed meal in women with normal glucose tolerance and gestational diabetes, and we assessed their gene expressions in different placental locations. Regarding the circulating levels of ANGPTL3, 4, and 8, we observed an absence of ANGPTL4 response after the intake of the meal in the GDM group compared to its presence in the control group. At the placental level, we observed a glucose tolerance-dependent expression pattern of <i>ANGPTL3</i> between the two placental sides. When we compared the GDM pregnancies with the con2023-01-01T00:00:00Z2023 Jan2025-04-25T19:23:53.046Z2025-04-06T07:57:48.176ZS-EPMC99170103676880910.3390/ijms24032486