{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu CH"],"funding":["National Institute of Allergy and Infectious Diseases","National Heart Lung and Blood Institute","Tri-Service General Hospital"],"pagination":["2382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9917043"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(3)"],"pubmed_abstract":["Tumor recurrence poses a significant challenge to the clinical management of stage I lung adenocarcinoma after curative surgical resection. Matrix metalloproteinases (MMPs) increase expression and correlate with recurrence and metastasis in surgically resected non-small cell lung cancer. However, the impact of MMPs on survival outcome varies, and their roles in patients with stage I lung adenocarcinoma remain unclear. In two discovery cohorts, we first analyzed 226 stage I-II lung adenocarcinoma cases in the GSE31210 cohort using a clustering-based method and identified a 150-gene MMP cluster with increased expression in tumors associated with worse survival outcomes. A similar analysis was performed on 517 lung adenocarcinoma cases in the Cancer Genome Atlas cohort. A 185-gene MMP cluster"],"journal":["International journal of molecular sciences"],"pubmed_title":["Matrix Metallopeptidase-Gene Signature Predicts Stage I Lung Adenocarcinoma Survival Outcomes."],"pmcid":["PMC9917043"],"funding_grant_id":["AI-133351","TSGH-E-111235","Health HL-125128"],"pubmed_authors":["Liu CH","Di YP"],"additional_accession":[]},"is_claimable":false,"name":"Matrix Metallopeptidase-Gene Signature Predicts Stage I Lung Adenocarcinoma Survival Outcomes.","description":"Tumor recurrence poses a significant challenge to the clinical management of stage I lung adenocarcinoma after curative surgical resection. Matrix metalloproteinases (MMPs) increase expression and correlate with recurrence and metastasis in surgically resected non-small cell lung cancer. However, the impact of MMPs on survival outcome varies, and their roles in patients with stage I lung adenocarcinoma remain unclear. In two discovery cohorts, we first analyzed 226 stage I-II lung adenocarcinoma cases in the GSE31210 cohort using a clustering-based method and identified a 150-gene MMP cluster with increased expression in tumors associated with worse survival outcomes. A similar analysis was performed on 517 lung adenocarcinoma cases in the Cancer Genome Atlas cohort. A 185-gene MMP cluster","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-25T19:20:47.181Z","creation":"2025-04-06T07:58:33.521Z"},"accession":"S-EPMC9917043","cross_references":{"pubmed":["36768704"],"doi":["10.3390/ijms24032382"]}}