{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kayashima Y"],"funding":["NICHD NIH HHS","NIH HHS"],"pagination":["2149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9917068"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(3)"],"pubmed_abstract":["Obesity is a risk factor for preeclampsia. We investigated how obesity influences preeclampsia in mice lacking ankyrin-repeat-and-SOCS-box-containing-protein 4 (ASB4), which promotes trophoblast differentiation via degrading the inhibitor of DNA-binding protein 2 (ID2). <i>Asb4<sup>-/-</sup></i> mice on normal chow (NC) develop mild preeclampsia-like phenotypes during pregnancy, including hypertension, proteinuria, and reduced litter size. Wild-type (WT) and <i>Asb4<sup>-/-</sup></i> females were placed on a high-fat diet (HFD) starting at weaning. At the age of 8-9 weeks, they were mated with WT or <i>Asb4<sup>-/-</sup></i> males, and preeclamptic phenotypes were assessed. HFD-WT dams had no obvious adverse outcomes of pregnancy. In contrast, HFD-<i>Asb4</i><sup>-/-</sup> dams had signifi"],"journal":["International journal of molecular sciences"],"pubmed_title":["Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice."],"pmcid":["PMC9917068"],"funding_grant_id":["R01 HD101485","R01HL049277, R01HD101485, P30 DK 034987"],"pubmed_authors":["Vora NL","Boggess K","Maeda-Smithies N","Homeister JW","Li F","Townley-Tilson WHD","Kayashima Y"],"additional_accession":[]},"is_claimable":false,"name":"Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice.","description":"Obesity is a risk factor for preeclampsia. We investigated how obesity influences preeclampsia in mice lacking ankyrin-repeat-and-SOCS-box-containing-protein 4 (ASB4), which promotes trophoblast differentiation via degrading the inhibitor of DNA-binding protein 2 (ID2). <i>Asb4<sup>-/-</sup></i> mice on normal chow (NC) develop mild preeclampsia-like phenotypes during pregnancy, including hypertension, proteinuria, and reduced litter size. Wild-type (WT) and <i>Asb4<sup>-/-</sup></i> females were placed on a high-fat diet (HFD) starting at weaning. At the age of 8-9 weeks, they were mated with WT or <i>Asb4<sup>-/-</sup></i> males, and preeclamptic phenotypes were assessed. HFD-WT dams had no obvious adverse outcomes of pregnancy. In contrast, HFD-<i>Asb4</i><sup>-/-</sup> dams had signifi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-05-29T22:23:22.89Z","creation":"2024-11-09T13:03:52.779Z"},"accession":"S-EPMC9917068","cross_references":{"pubmed":["36768469"],"doi":["10.3390/ijms24032149"]}}