{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gianniou DD"],"funding":["General Secretariat for Research and Technology"],"pagination":["2609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9917356"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(3)"],"pubmed_abstract":["Bladder cancer (BlCa) represents the sixth most commonly diagnosed type of male malignancy. Due to the clinical heterogeneity of BlCa, novel markers would optimize treatment efficacy and improve prognosis. The small heat shock proteins (sHSP) family is one of the major groups of molecular chaperones responsible for the maintenance of proteome functionality and stability. However, the role of sHSPs in BlCa remains largely unknown. The present study aimed to examine the association between <i>HSPB2</i> and <i>HSPB3</i> expression and BlCa progression in patients, and to investigate their role in BlCa cells. For this purpose, a series of experiments including reverse transcription-quantitative PCR, Western blotting, MTT assay and flow cytometry were performed. Initial analyses revealed increa"],"journal":["International journal of molecular sciences"],"pubmed_title":["Evaluation of the Small Heat Shock Protein Family Members <i>HSPB2</i> and <i>HSPB3</i> in Bladder Cancer Prognosis and Progression."],"pmcid":["PMC9917356"],"funding_grant_id":["T2EDK-02423"],"pubmed_authors":["Sklirou AD","Scorilas A","Gianniou DD","Avgeris M","Papadimitriou MA","Trougakos IP","Pilala KM","Stravodimos K"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of the Small Heat Shock Protein Family Members <i>HSPB2</i> and <i>HSPB3</i> in Bladder Cancer Prognosis and Progression.","description":"Bladder cancer (BlCa) represents the sixth most commonly diagnosed type of male malignancy. Due to the clinical heterogeneity of BlCa, novel markers would optimize treatment efficacy and improve prognosis. The small heat shock proteins (sHSP) family is one of the major groups of molecular chaperones responsible for the maintenance of proteome functionality and stability. However, the role of sHSPs in BlCa remains largely unknown. The present study aimed to examine the association between <i>HSPB2</i> and <i>HSPB3</i> expression and BlCa progression in patients, and to investigate their role in BlCa cells. For this purpose, a series of experiments including reverse transcription-quantitative PCR, Western blotting, MTT assay and flow cytometry were performed. Initial analyses revealed increa","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-04-08T14:15:18.859Z","creation":"2025-02-19T02:24:07.88Z"},"accession":"S-EPMC9917356","cross_references":{"pubmed":["36768927"],"doi":["10.3390/ijms24032609"]}}