biostudies-literatureKallmeyer AInstituto de Salud Carlos III FEDERMinistry of Science and innovationInstituto de Salud Carlos III (ISCIII)960https://www.ebi.ac.uk/biostudies/studies/S-EPMC9917543biostudies-literatureUnknown12(3)The pathophysiological mechanisms underlying Myocardial Infarction with Non-Obstructive Coronary Artery Disease (MINOCA) are still under debate. Lipoprotein (a) [Lp(a)] has proinflammatory and prothrombotic actions and has been involved in the pathogenesis of atherosclerosis. However, no previous studies have linked Lp(a) levels with the probability of developing MINOCA. Moreover, the relationship between MINOCA and the plasma levels of other proatherogenic and proinflammatory molecules such as Interleukin-18 (IL18) and proprotein convertase subtilisin/kexin type 9 (PCSK9) has not been studied. We conducted a prospective, multicenter study involving 1042 patients with acute myocardial infarction (AMI). Seventy-six patients had no significant coronary lesions. All patients underwent plasma Journal of clinical medicineAbsence of High Lipoprotein(a) Levels Is an Independent Predictor of Acute Myocardial Infarction without Coronary Lesions.PMC9917543RD09/0076/00101PI22/00233RTC2019-006826-1PI17/01495PI20/00923PI19/00128Gonzalez-Lorenzo OTunon JHuelmos ALopez-Castillo MLorenzo OLumpuy-Castillo JLopez-Bescos LGutierrez-Landaluce CCristobal CAcena APello Lazaro AMTarin NKallmeyer ABlanco-Colio LMAlonso Martin JJEgido JMontalvo JMfalseAbsence of High Lipoprotein(a) Levels Is an Independent Predictor of Acute Myocardial Infarction without Coronary Lesions.The pathophysiological mechanisms underlying Myocardial Infarction with Non-Obstructive Coronary Artery Disease (MINOCA) are still under debate. Lipoprotein (a) [Lp(a)] has proinflammatory and prothrombotic actions and has been involved in the pathogenesis of atherosclerosis. However, no previous studies have linked Lp(a) levels with the probability of developing MINOCA. Moreover, the relationship between MINOCA and the plasma levels of other proatherogenic and proinflammatory molecules such as Interleukin-18 (IL18) and proprotein convertase subtilisin/kexin type 9 (PCSK9) has not been studied. We conducted a prospective, multicenter study involving 1042 patients with acute myocardial infarction (AMI). Seventy-six patients had no significant coronary lesions. All patients underwent plasma 2023-01-01T00:00:00Z2023 Jan2025-08-18T09:53:32.493Z2025-08-18T09:53:32.493ZS-EPMC99175433676960810.3390/jcm12030960