biostudies-literatureWang DScientific and Technological Innovation Project of China Academy of Chinese Medical SciencesNational Natural Science Foundation of China1078https://www.ebi.ac.uk/biostudies/studies/S-EPMC9917633biostudies-literatureUnknown12(3)Abnormal platelet activation can lead to thrombosis in essential thrombocythemia (ET) and thus impact patient prognosis. Platelet activation-associated proteins are key molecules for platelet activation. However, it is unclear which proteins are most closely associated with the disease's prognosis. To determine which platelet activation-related proteins can be employed as ET patient prognosis predictors, we used label-free quantification (LFQ) and parallel reaction monitoring (PRM) technology and first determined the serum proteomic expression levels and the differential proteins of ET patients. Then, based on the IPSET (International Prognostic Score for ET), the differential protein associated with the prognostic score was found. To investigate potential processes affecting prognosis, thJournal of clinical medicineProteomic-Based Platelet Activation-Associated Protein SELP May Be a Novel Biomarker for Coagulation and Prognostic in Essential Thrombocythemia.PMC9917633CI2021A01708No. 82174360CI2021A01702Chen KWang DLv YHu XSun YYang ELiu WWang MLi YChen ZZhang YZhao PNiu JChen YWang ZMing JfalseProteomic-Based Platelet Activation-Associated Protein SELP May Be a Novel Biomarker for Coagulation and Prognostic in Essential Thrombocythemia.Abnormal platelet activation can lead to thrombosis in essential thrombocythemia (ET) and thus impact patient prognosis. Platelet activation-associated proteins are key molecules for platelet activation. However, it is unclear which proteins are most closely associated with the disease's prognosis. To determine which platelet activation-related proteins can be employed as ET patient prognosis predictors, we used label-free quantification (LFQ) and parallel reaction monitoring (PRM) technology and first determined the serum proteomic expression levels and the differential proteins of ET patients. Then, based on the IPSET (International Prognostic Score for ET), the differential protein associated with the prognostic score was found. To investigate potential processes affecting prognosis, th2023-01-01T00:00:00Z2023 Jan2025-04-25T19:23:58.924Z2025-04-06T07:56:51.35ZS-EPMC99176333676972510.3390/jcm12031078