biostudies-literatureZahr TNIDDK NIH HHSNHLBI NIH HHSNIGMS NIH HHS30-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC9917767biostudies-literatureUnknown43(1)<h4>Background</h4>Atherosclerosis is a medical urgency manifesting at the onset of hypercholesterolemia and is associated with aging. Activation of PPARγ (peroxisome proliferator-activated receptor γ) counteracts metabolic dysfunction influenced by aging, and its deacetylation displays an atheroprotective property. Despite the marked increase of PPARγ acetylation during aging, it is unknown whether PPARγ acetylation is a pathogenic contributor to aging-associated atherosclerosis.<h4>Methods</h4>Mice with constitutive deacetylation-mimetic PPARγ mutations on lysine residues K268 and K293 (2KR) in an LDL (low-density lipoprotein)-receptor knockout (<i>Ldlr</i>^-/-) background (<i>2KR:Ldlr</i>^-/-) were aged for 18 months on a standard laboratory diet to examine the cardiArteriosclerosis, thrombosis, and vascular biologyPPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia.PMC9917767P01 HL087123R01 DK131169R35 GM147269R01 DK112943R01 DK128848R00 DK115778Cai BSun LLiu LChan MZhou QHe YAccili DZahr TAaron NQiang LfalsePPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia.<h4>Background</h4>Atherosclerosis is a medical urgency manifesting at the onset of hypercholesterolemia and is associated with aging. Activation of PPARγ (peroxisome proliferator-activated receptor γ) counteracts metabolic dysfunction influenced by aging, and its deacetylation displays an atheroprotective property. Despite the marked increase of PPARγ acetylation during aging, it is unknown whether PPARγ acetylation is a pathogenic contributor to aging-associated atherosclerosis.<h4>Methods</h4>Mice with constitutive deacetylation-mimetic PPARγ mutations on lysine residues K268 and K293 (2KR) in an LDL (low-density lipoprotein)-receptor knockout (<i>Ldlr</i>^-/-) background (<i>2KR:Ldlr</i>^-/-) were aged for 18 months on a standard laboratory diet to examine the cardi2023-01-01T00:00:00Z2023 Jan2025-04-04T03:01:01.945Z2025-04-04T03:01:01.945ZS-EPMC99177673645327910.1161/ATVBAHA.122.31806110.1161/atvbaha.122.318061