biostudies-literatureLuo Zthe S&T Program of Hebeithe National Key Research and Development Program of Chinathe Medical Science Research Project of Hebei ProvinceHebei Provincial Government Funded Clinical Medicine Excellent Talent ProgramHebei Natural Science Foundation (Beijing-Tianjin-Hebei Cooperation Special Project)818https://www.ebi.ac.uk/biostudies/studies/S-EPMC9918062biostudies-literatureUnknown12(3)<h4>Background</h4>Ovarian sensitivity index (OSI) is an accurate index to reflect the ovarian sensitivity to exogenous gonadotropins in in vitro fertilization (IVF). How insulin resistance (IR) affects OSI and pregnancy outcomes during IVF remains unclear.<h4>Methods</h4>This was a large retrospective, cohort study. A total of 2055 women with polycystic ovary syndrome (PCOS) undergoing the first fresh IVF cycle were enrolled. They were grouped into terciles based on the homeostasis model assessment of insulin resistance (HOMA-IR) values as control, medium and IR group for comparison. Multivariate regression analysis was also conducted.<h4>Results</h4>HOMA-IR had a significantly negative impact on OSI (adjusted β = -0.24; 95% CI, -0.35 to -0.13), especially in lean patients with an adjusteJournal of clinical medicineImpact of Insulin Resistance on Ovarian Sensitivity and Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome Undergoing IVF.PMC991806221377760D2021YFC2700605H2019206707202120190519Jiang LFan YLuo ZHao GDu YWang YXu XWang LfalseImpact of Insulin Resistance on Ovarian Sensitivity and Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome Undergoing IVF.<h4>Background</h4>Ovarian sensitivity index (OSI) is an accurate index to reflect the ovarian sensitivity to exogenous gonadotropins in in vitro fertilization (IVF). How insulin resistance (IR) affects OSI and pregnancy outcomes during IVF remains unclear.<h4>Methods</h4>This was a large retrospective, cohort study. A total of 2055 women with polycystic ovary syndrome (PCOS) undergoing the first fresh IVF cycle were enrolled. They were grouped into terciles based on the homeostasis model assessment of insulin resistance (HOMA-IR) values as control, medium and IR group for comparison. Multivariate regression analysis was also conducted.<h4>Results</h4>HOMA-IR had a significantly negative impact on OSI (adjusted β = -0.24; 95% CI, -0.35 to -0.13), especially in lean patients with an adjuste2023-01-01T00:00:00Z2023 Jan2025-05-29T22:24:09.973Z2025-04-19T19:39:01.935ZS-EPMC99180623676946710.3390/jcm12030818