{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hay A"],"funding":["NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["50-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9918384"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>The Red blood cell (RBC) storage lesion results in decreased circulation and function of transfused RBCs. Elevated oxidant stress and impaired energy metabolism are a hallmark of the storage lesion in both human and murine RBCs. Although human studies don't suffer concerns that findings may not translate, they do suffer from genetic and environmental variability amongst subjects. Murine models can control for genetics, environment, and much interventional experimentation can be carried out in mice that is neither technically feasible nor ethical in humans. However, murine models are only useful to the extent that they have similar biology to humans. Hypoxic storage has been shown to mitigate the storage lesion in human RBCs, but has not been investigated in mice.<h4>Mate"],"journal":["Blood transfusion = Trasfusione del sangue"],"pubmed_title":["Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries."],"pmcid":["PMC9918384"],"funding_grant_id":["R01 HL146442","R01 HL161004","R21 HL150032","R01 HL148151","RM1 GM131968"],"pubmed_authors":["D'Alessandro A","Nerguizian D","Hay A","Dzieciatkowska M","Dziewulska K","Gamboni F","Zimring JC"],"additional_accession":[]},"is_claimable":false,"name":"Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries.","description":"<h4>Background</h4>The Red blood cell (RBC) storage lesion results in decreased circulation and function of transfused RBCs. Elevated oxidant stress and impaired energy metabolism are a hallmark of the storage lesion in both human and murine RBCs. Although human studies don't suffer concerns that findings may not translate, they do suffer from genetic and environmental variability amongst subjects. Murine models can control for genetics, environment, and much interventional experimentation can be carried out in mice that is neither technically feasible nor ethical in humans. However, murine models are only useful to the extent that they have similar biology to humans. Hypoxic storage has been shown to mitigate the storage lesion in human RBCs, but has not been investigated in mice.<h4>Mate","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-18T21:31:43.355Z","creation":"2025-04-07T09:21:59.666Z"},"accession":"S-EPMC9918384","cross_references":{"pubmed":["36346885"],"doi":["10.2450/2022.0172-22"]}}