biostudies-literatureVictorson DNational Cancer InstituteNCI NIH HHSNational Institutes of Health107059https://www.ebi.ac.uk/biostudies/studies/S-EPMC9918709biostudies-literatureUnknown125<h4>Background</h4>Although active surveillance (AS) is an increasingly adopted treatment paradigm for management of very low risk prostate cancer, many men and their partners face a variety of AS-related psychosocial stressors. Stressors may include anxiety and fear of progression, which may negatively affect short- and long-term psychosocial adjustment and influence early withdrawal from AS in order to seek definitive therapies such as surgery or radiation. Here we describe the protocol for an NCI-funded trial, which seeks to examine the efficacy of mindfulness training compared with a time/attention-matched health promotion control condition in a geographically generalizable sample of men on AS and their spouses.<h4>Methods</h4>Using a randomized, controlled, partially double-blinded stContemporary clinical trialsMindfulness-based stress reduction for men on active surveillance for prostate cancer and their spouses: Design and methodology of a randomized controlled trial.PMC9918709R01 CA193331CA193193T32 CA193193NCT02871752R01CA193331Horowitz BNovakovic KBrendler CMurphy KMorgan TVictorson DAddington EKutikov AJackson KSauer CKundu SfalseMindfulness-based stress reduction for men on active surveillance for prostate cancer and their spouses: Design and methodology of a randomized controlled trial.<h4>Background</h4>Although active surveillance (AS) is an increasingly adopted treatment paradigm for management of very low risk prostate cancer, many men and their partners face a variety of AS-related psychosocial stressors. Stressors may include anxiety and fear of progression, which may negatively affect short- and long-term psychosocial adjustment and influence early withdrawal from AS in order to seek definitive therapies such as surgery or radiation. Here we describe the protocol for an NCI-funded trial, which seeks to examine the efficacy of mindfulness training compared with a time/attention-matched health promotion control condition in a geographically generalizable sample of men on AS and their spouses.<h4>Methods</h4>Using a randomized, controlled, partially double-blinded st2023-01-01T00:00:00Z2023 Feb2025-04-26T11:55:18.77Z2025-02-19T04:59:45.068ZS-EPMC99187093656390210.1016/j.cct.2022.107059