biostudies-literatureCordeiro R“Fundação para a Ciência e a Tecnologia” FCT/MCTES (PIDDAC)Fundação para a Ciência e TecnologiaSpanish Foundation for Science and Technologythe institutional scientific employment program-contractAgencia de Inovacao781https://www.ebi.ac.uk/biostudies/studies/S-EPMC9919712biostudies-literatureUnknown15(3)Osteoarthritis is a highly prevalent disease worldwide that leads to cartilage loss. Tissue engineering, involving scaffolds, cells, and stimuli, has shown to be a promising strategy for its repair. Thus, this study aims to manufacture and characterise different scaffolds with poly(ε-caprolactone) (PCL) with commercial cellulose (microcrystalline (McC) and methyl cellulose (MC) or cellulose from agro-industrial residues (corncob (CcC)) and at different percentages, 1%, 2%, and 3%. PCL scaffolds were used as a control. Morphologically, the produced scaffolds presented porosities within the desired for cell incorporation (57% to 65%). When submitted to mechanical tests, the incorporation of cellulose affects the compression resistance of the majority of scaffolds. Regarding tensile strength,PolymersCellulose-Based Scaffolds: A Comparative Study for Potential Application in Articular Cartilage.PMC99197122022.09638.BDCEECINST/00077/2021UIDB/04044/2020; UIDP/04044/2020; 2022.09638.BD; Associate Laboratory ARISE LA/P/0112/2020; PAMI - ROTEIRO/0328/2013 (Nº 022158)PAMI—ROTEIRO/0328/2013 (N° 022158)BIODISCUS (CENTRE-01-0247-FEDER-039969)UIDP/04044/2020Associate Laboratory ARISE LA/P/0112/2020UIDB/04044/2020Lopes BCordeiro RSousa PMauricio ACSousa ACAlves NMoura CAlvites RDfalseCellulose-Based Scaffolds: A Comparative Study for Potential Application in Articular Cartilage.Osteoarthritis is a highly prevalent disease worldwide that leads to cartilage loss. Tissue engineering, involving scaffolds, cells, and stimuli, has shown to be a promising strategy for its repair. Thus, this study aims to manufacture and characterise different scaffolds with poly(ε-caprolactone) (PCL) with commercial cellulose (microcrystalline (McC) and methyl cellulose (MC) or cellulose from agro-industrial residues (corncob (CcC)) and at different percentages, 1%, 2%, and 3%. PCL scaffolds were used as a control. Morphologically, the produced scaffolds presented porosities within the desired for cell incorporation (57% to 65%). When submitted to mechanical tests, the incorporation of cellulose affects the compression resistance of the majority of scaffolds. Regarding tensile strength,2023-01-01T00:00:00Z2023 Feb2025-08-17T03:07:36.159Z2025-04-06T07:57:31.985ZS-EPMC99197123677208310.3390/polym15030781