{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lozinskaya NA"],"funding":["Russian Science Foundation"],"pagination":["1174"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9920986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(3)"],"pubmed_abstract":["The enzyme NRH:quinone oxidoreductase 2 (NQO2) plays an important role in the pathogenesis of various diseases such as neurodegenerative disorders, malaria, glaucoma, COVID-19 and cancer. NQO2 expression is known to be increased in some cancer cell lines. Since 3-arylidene-2-oxindoles are widely used in the design of new anticancer drugs, such as kinase inhibitors, it was interesting to study whether such structures have additional activity towards NQO2. Herein, we report the synthesis and study of 3-arylidene-2-oxindoles as novel NRH:quinone oxidoreductase inhibitors. It was demonstrated that oxindoles with 6-membered aryls in the arylidene moiety were obtained predominantly as <i>E</i>-isomers while for some 5-membered aryls, the <i>Z</i>-isomers prevailed. The most active compounds inhi"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["3-Arylidene-2-oxindoles as Potent NRH:Quinone Oxidoreductase 2 Inhibitors."],"pmcid":["PMC9920986"],"funding_grant_id":["22-23-20141"],"pubmed_authors":["Lozinskaya NA","Bezsonova EN","Melekhina DD","Sosonyuk SE","Sokolova EV","Spasov AA","Bunev AS","Grigor'eva OB","Babkov DA","Dubar M","Bazanov DR","Klochkov VG"],"additional_accession":[]},"is_claimable":false,"name":"3-Arylidene-2-oxindoles as Potent NRH:Quinone Oxidoreductase 2 Inhibitors.","description":"The enzyme NRH:quinone oxidoreductase 2 (NQO2) plays an important role in the pathogenesis of various diseases such as neurodegenerative disorders, malaria, glaucoma, COVID-19 and cancer. NQO2 expression is known to be increased in some cancer cell lines. Since 3-arylidene-2-oxindoles are widely used in the design of new anticancer drugs, such as kinase inhibitors, it was interesting to study whether such structures have additional activity towards NQO2. Herein, we report the synthesis and study of 3-arylidene-2-oxindoles as novel NRH:quinone oxidoreductase inhibitors. It was demonstrated that oxindoles with 6-membered aryls in the arylidene moiety were obtained predominantly as <i>E</i>-isomers while for some 5-membered aryls, the <i>Z</i>-isomers prevailed. The most active compounds inhi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-04-08T13:28:02.884Z","creation":"2025-02-19T04:46:11.67Z"},"accession":"S-EPMC9920986","cross_references":{"pubmed":["36770840"],"doi":["10.3390/molecules28031174"]}}