{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ratitong B"],"funding":["NEI NIH HHS","NIH","NIH HHS"],"pagination":["548-558"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9922050"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["209(3)"],"pubmed_abstract":["Pseudomonas aeruginosa is an important cause of dermal, pulmonary, and ocular disease. Our studies have focused on P. aeruginosa infections of the cornea (keratitis) as a major cause of blinding microbial infections. The infection leads to an influx of innate immune cells, with neutrophils making up to 90% of recruited cells during early stages. We previously reported that the proinflammatory cytokines IL-1α and IL-1β were elevated during infection. Compared with wild-type (WT), infected Il1b-/- mice developed more severe corneal disease that is associated with impaired bacterial killing as a result of defective neutrophil recruitment. We also reported that neutrophils are an important source of IL-1α and IL-1β, which peaked at 24 h postinfection. To examine the role of IL-1α compared with"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Differential Roles for IL-1α and IL-1β in Pseudomonas aeruginosa Corneal Infection."],"pmcid":["PMC9922050"],"funding_grant_id":["R01 EY14362","R01 EY018612","F31 EY032312-02","R01 EY014362","F31 EY032312"],"pubmed_authors":["Marshall ME","Ratitong B","Pearlman E","Abbondante S","Dragan MA","Anunciado CM"],"additional_accession":[]},"is_claimable":false,"name":"Differential Roles for IL-1α and IL-1β in Pseudomonas aeruginosa Corneal Infection.","description":"Pseudomonas aeruginosa is an important cause of dermal, pulmonary, and ocular disease. Our studies have focused on P. aeruginosa infections of the cornea (keratitis) as a major cause of blinding microbial infections. The infection leads to an influx of innate immune cells, with neutrophils making up to 90% of recruited cells during early stages. We previously reported that the proinflammatory cytokines IL-1α and IL-1β were elevated during infection. Compared with wild-type (WT), infected Il1b-/- mice developed more severe corneal disease that is associated with impaired bacterial killing as a result of defective neutrophil recruitment. We also reported that neutrophils are an important source of IL-1α and IL-1β, which peaked at 24 h postinfection. To examine the role of IL-1α compared with","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T21:13:46.03Z","creation":"2025-02-19T03:05:39.958Z"},"accession":"S-EPMC9922050","cross_references":{"pubmed":["35851538"],"doi":["10.4049/jimmunol.2200110"]}}