biostudies-literatureRatitong BNEI NIH HHSNIHNIH HHS548-558https://www.ebi.ac.uk/biostudies/studies/S-EPMC9922050biostudies-literatureUnknown209(3)Pseudomonas aeruginosa is an important cause of dermal, pulmonary, and ocular disease. Our studies have focused on P. aeruginosa infections of the cornea (keratitis) as a major cause of blinding microbial infections. The infection leads to an influx of innate immune cells, with neutrophils making up to 90% of recruited cells during early stages. We previously reported that the proinflammatory cytokines IL-1α and IL-1β were elevated during infection. Compared with wild-type (WT), infected Il1b-/- mice developed more severe corneal disease that is associated with impaired bacterial killing as a result of defective neutrophil recruitment. We also reported that neutrophils are an important source of IL-1α and IL-1β, which peaked at 24 h postinfection. To examine the role of IL-1α compared withJournal of immunology (Baltimore, Md. : 1950)Differential Roles for IL-1α and IL-1β in Pseudomonas aeruginosa Corneal Infection.PMC9922050R01 EY14362R01 EY018612F31 EY032312-02R01 EY014362F31 EY032312Marshall MERatitong BPearlman EAbbondante SDragan MAAnunciado CMfalseDifferential Roles for IL-1α and IL-1β in Pseudomonas aeruginosa Corneal Infection.Pseudomonas aeruginosa is an important cause of dermal, pulmonary, and ocular disease. Our studies have focused on P. aeruginosa infections of the cornea (keratitis) as a major cause of blinding microbial infections. The infection leads to an influx of innate immune cells, with neutrophils making up to 90% of recruited cells during early stages. We previously reported that the proinflammatory cytokines IL-1α and IL-1β were elevated during infection. Compared with wild-type (WT), infected Il1b-/- mice developed more severe corneal disease that is associated with impaired bacterial killing as a result of defective neutrophil recruitment. We also reported that neutrophils are an important source of IL-1α and IL-1β, which peaked at 24 h postinfection. To examine the role of IL-1α compared with2022-01-01T00:00:00Z2022 Aug2025-04-04T21:13:46.03Z2025-02-19T03:05:39.958ZS-EPMC99220503585153810.4049/jimmunol.2200110