{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su Y"],"funding":["NINDS NIH HHS"],"pagination":["190-201.e8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9922530"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(2)"],"pubmed_abstract":["Oligodendrocyte precursor cells (OPCs) undergo an extensive and coordinated migration in the developing CNS, using the pre-formed scaffold of developed blood vessels as their physical substrate for migration. While OPC association with vasculature is critical for dispersal, equally important for permitting differentiation and proper myelination of target axons is their appropriate and timely detachment, but regulation of this process remains unclear. Here we demonstrate a correlation between the developmental formation of astrocytic endfeet on vessels and the termination of OPC perivascular migration. Ex vivo and in vivo live imaging shows that astrocyte endfeet physically displace OPCs from vasculature, and genetic abrogation of endfoot formation hinders both OPC detachment from vessels a"],"journal":["Neuron"],"pubmed_title":["Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development."],"pmcid":["PMC9922530"],"funding_grant_id":["R21 NS133891","P01 NS083513","R21 NS119954","R01 NS097551"],"pubmed_authors":["Li H","Chen L","Fancy SPJ","Yu G","Xia W","Verkhratsky A","Yang Y","Wang Q","Xiao L","Wang S","Hoi KK","Niu J","Yi C","Wang X","Chen X","Su Y","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development.","description":"Oligodendrocyte precursor cells (OPCs) undergo an extensive and coordinated migration in the developing CNS, using the pre-formed scaffold of developed blood vessels as their physical substrate for migration. While OPC association with vasculature is critical for dispersal, equally important for permitting differentiation and proper myelination of target axons is their appropriate and timely detachment, but regulation of this process remains unclear. Here we demonstrate a correlation between the developmental formation of astrocytic endfeet on vessels and the termination of OPC perivascular migration. Ex vivo and in vivo live imaging shows that astrocyte endfeet physically displace OPCs from vasculature, and genetic abrogation of endfoot formation hinders both OPC detachment from vessels a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T21:55:09.209Z","creation":"2025-04-03T23:50:47.835Z"},"accession":"S-EPMC9922530","cross_references":{"pubmed":["36384142"],"doi":["10.1016/j.neuron.2022.10.032"]}}