{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(2)"],"submitter":["Bak SG"],"pubmed_abstract":["<i>Vigna angularis</i> is an edible crop and herbal medicine that is known to have antipyretic, anti-inflammatory, and anti-edema effects. Many studies have been conducted on the 95% ethanol extract of <i>V. angularis</i>, but there is little research on the 70% ethanol extract and hemiphloin, which is a new indicator component of the 70% ethanol extract of <i>V. angularis</i>. To investigate the <i>in vitro</i> anti-atopic effect and verify the mechanism action of 70% ethanol extract of <i>V. angularis</i> (VAE), TNF-α/IFN-γ-induced HaCaT keratinocytes were used. The VAE treatment alleviated TNF-α/IFN-γ-induced IL-1β, IL-6, IL-8, CCL17/TARC, and CCL22/MDC gene expressions and productions. VAE also inhibited the phosphorylation of MAPKs, including p38, ERK, JNK, STAT1, and NF-κB in TNF-α/I"],"journal":["Heliyon"],"pagination":["e12994"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9922827"],"repository":["biostudies-literature"],"pubmed_title":["Effects of <i>Vigna angularis</i> extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation."],"pmcid":["PMC9922827"],"pubmed_authors":["Won YS","Lee S","Rho MC","Lee SJ","Lee SW","Lim HJ","Park EJ","Park SI","Bak SG"],"additional_accession":[]},"is_claimable":false,"name":"Effects of <i>Vigna angularis</i> extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation.","description":"<i>Vigna angularis</i> is an edible crop and herbal medicine that is known to have antipyretic, anti-inflammatory, and anti-edema effects. Many studies have been conducted on the 95% ethanol extract of <i>V. angularis</i>, but there is little research on the 70% ethanol extract and hemiphloin, which is a new indicator component of the 70% ethanol extract of <i>V. angularis</i>. To investigate the <i>in vitro</i> anti-atopic effect and verify the mechanism action of 70% ethanol extract of <i>V. angularis</i> (VAE), TNF-α/IFN-γ-induced HaCaT keratinocytes were used. The VAE treatment alleviated TNF-α/IFN-γ-induced IL-1β, IL-6, IL-8, CCL17/TARC, and CCL22/MDC gene expressions and productions. VAE also inhibited the phosphorylation of MAPKs, including p38, ERK, JNK, STAT1, and NF-κB in TNF-α/I","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T11:16:34.526Z","creation":"2025-04-04T11:16:34.526Z"},"accession":"S-EPMC9922827","cross_references":{"pubmed":["36793948"],"doi":["10.1016/j.heliyon.2023.e12994"]}}