biostudies-literatureUnknown9(2)Bak SG<i>Vigna angularis</i> is an edible crop and herbal medicine that is known to have antipyretic, anti-inflammatory, and anti-edema effects. Many studies have been conducted on the 95% ethanol extract of <i>V. angularis</i>, but there is little research on the 70% ethanol extract and hemiphloin, which is a new indicator component of the 70% ethanol extract of <i>V. angularis</i>. To investigate the <i>in vitro</i> anti-atopic effect and verify the mechanism action of 70% ethanol extract of <i>V. angularis</i> (VAE), TNF-α/IFN-γ-induced HaCaT keratinocytes were used. The VAE treatment alleviated TNF-α/IFN-γ-induced IL-1β, IL-6, IL-8, CCL17/TARC, and CCL22/MDC gene expressions and productions. VAE also inhibited the phosphorylation of MAPKs, including p38, ERK, JNK, STAT1, and NF-κB in TNF-α/IHeliyone12994https://www.ebi.ac.uk/biostudies/studies/S-EPMC9922827biostudies-literatureEffects of <i>Vigna angularis</i> extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation.PMC9922827Won YSLee SRho MCLee SJLee SWLim HJPark EJPark SIBak SGfalseEffects of <i>Vigna angularis</i> extract and its active compound hemiphloin against atopic dermatitis-like skin inflammation.<i>Vigna angularis</i> is an edible crop and herbal medicine that is known to have antipyretic, anti-inflammatory, and anti-edema effects. Many studies have been conducted on the 95% ethanol extract of <i>V. angularis</i>, but there is little research on the 70% ethanol extract and hemiphloin, which is a new indicator component of the 70% ethanol extract of <i>V. angularis</i>. To investigate the <i>in vitro</i> anti-atopic effect and verify the mechanism action of 70% ethanol extract of <i>V. angularis</i> (VAE), TNF-α/IFN-γ-induced HaCaT keratinocytes were used. The VAE treatment alleviated TNF-α/IFN-γ-induced IL-1β, IL-6, IL-8, CCL17/TARC, and CCL22/MDC gene expressions and productions. VAE also inhibited the phosphorylation of MAPKs, including p38, ERK, JNK, STAT1, and NF-κB in TNF-α/I2023-01-01T00:00:00Z2023 Feb2025-04-04T11:16:34.526Z2025-04-04T11:16:34.526ZS-EPMC99228273679394810.1016/j.heliyon.2023.e12994