{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Sullivan MN"],"pubmed_abstract":["<b>Introduction:</b> Hypoxia-induced dilation of cerebral arteries orchestrated by Ca<sup>2+</sup>-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has a similar impact during hemorrhagic stroke. TRPA1 channels are endogenously activated by lipid peroxide metabolites generated by reactive oxygen species (ROS). Uncontrolled hypertension, a primary risk factor for the development of hemorrhagic stroke, is associated with increased ROS production and oxidative stress. Therefore, we hypothesized that TRPA1 channel activity is increased during hemorrhagic stroke. <b>Methods:</b> Severe, chronic hypertension was induced in control (<i>Trpa1</i> <sup>fl/fl</sup>) and endothelia"],"journal":["Frontiers in molecular biosciences"],"pagination":["1129435"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9922848"],"repository":["biostudies-literature"],"pubmed_title":["Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension."],"pmcid":["PMC9922848"],"pubmed_authors":["Li W","Sullivan MN","Krishnan V","Thakore P","Earley S","Feng Earley Y","Alphonsa S"],"additional_accession":[]},"is_claimable":false,"name":"Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.","description":"<b>Introduction:</b> Hypoxia-induced dilation of cerebral arteries orchestrated by Ca<sup>2+</sup>-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has a similar impact during hemorrhagic stroke. TRPA1 channels are endogenously activated by lipid peroxide metabolites generated by reactive oxygen species (ROS). Uncontrolled hypertension, a primary risk factor for the development of hemorrhagic stroke, is associated with increased ROS production and oxidative stress. Therefore, we hypothesized that TRPA1 channel activity is increased during hemorrhagic stroke. <b>Methods:</b> Severe, chronic hypertension was induced in control (<i>Trpa1</i> <sup>fl/fl</sup>) and endothelia","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-05T10:36:20.55Z","creation":"2025-04-05T10:36:20.55Z"},"accession":"S-EPMC9922848","cross_references":{"pubmed":["36793787"],"doi":["10.3389/fmolb.2023.1129435"]}}