biostudies-literatureUnknown10Sullivan MN<b>Introduction:</b> Hypoxia-induced dilation of cerebral arteries orchestrated by Ca²⁺-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has a similar impact during hemorrhagic stroke. TRPA1 channels are endogenously activated by lipid peroxide metabolites generated by reactive oxygen species (ROS). Uncontrolled hypertension, a primary risk factor for the development of hemorrhagic stroke, is associated with increased ROS production and oxidative stress. Therefore, we hypothesized that TRPA1 channel activity is increased during hemorrhagic stroke. <b>Methods:</b> Severe, chronic hypertension was induced in control (<i>Trpa1</i> ^fl/fl) and endotheliaFrontiers in molecular biosciences1129435https://www.ebi.ac.uk/biostudies/studies/S-EPMC9922848biostudies-literatureEndothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.PMC9922848Li WSullivan MNKrishnan VThakore PEarley SFeng Earley YAlphonsa SfalseEndothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.<b>Introduction:</b> Hypoxia-induced dilation of cerebral arteries orchestrated by Ca²⁺-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has a similar impact during hemorrhagic stroke. TRPA1 channels are endogenously activated by lipid peroxide metabolites generated by reactive oxygen species (ROS). Uncontrolled hypertension, a primary risk factor for the development of hemorrhagic stroke, is associated with increased ROS production and oxidative stress. Therefore, we hypothesized that TRPA1 channel activity is increased during hemorrhagic stroke. <b>Methods:</b> Severe, chronic hypertension was induced in control (<i>Trpa1</i> ^fl/fl) and endothelia2023-01-01T00:00:00Z20232025-04-05T10:36:20.55Z2025-04-05T10:36:20.55ZS-EPMC99228483679378710.3389/fmolb.2023.1129435