{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["De Oliveira Silva D"],"funding":["La Trobe Sport and Exercise Medicine (LASEM) research centre","La Trobe University Themes ABC Grant","Arthritis Australia","National Health and Medical Research Council"],"pagination":["e068040"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9923264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(2)"],"pubmed_abstract":["<h4>Introduction</h4>Running is one of the most popular recreational activities worldwide, due to its low cost and accessibility. However, little is known about the impact of running on knee joint health in runners with and without a history of knee surgery. The primary aim of this longitudinal cohort study is to compare knee joint structural features on MRI and knee symptoms at baseline and 4-year follow-up in runners with and without a history of knee surgery. Secondary aims are to explore the relationships between training load exposures (volume and/or intensity) and changes in knee joint structure and symptoms over 4 years; explore the relationship between baseline running biomechanics, and changes in knee joint structure and symptoms over 4 years. In addition, we will explore whether "],"journal":["BMJ open"],"pubmed_title":["Trajectory of knee health in runners with and without heightened osteoarthritis risk: the TRAIL prospective cohort study protocol."],"pmcid":["PMC9923264"],"funding_grant_id":["N/A","GNT2008523","GNT1190882"],"pubmed_authors":["Briggs C","West TJ","Girdwood M","Pedoia V","Mentiplay BF","Hulett M","Souza RB","Haberfield MJ","Patterson BE","Warden SJ","Alexander JL","Johnston RTR","Schache AG","Telles GF","Hedger MP","De Oliveira Silva D","Crossley KM","Semciw AI","Bruder AM","Culvenor AG","Hill JP","Pappalardo PJ","Barton CJ","Sritharan P","Carey DL","Oei EH","King MG"],"additional_accession":[]},"is_claimable":false,"name":"Trajectory of knee health in runners with and without heightened osteoarthritis risk: the TRAIL prospective cohort study protocol.","description":"<h4>Introduction</h4>Running is one of the most popular recreational activities worldwide, due to its low cost and accessibility. However, little is known about the impact of running on knee joint health in runners with and without a history of knee surgery. The primary aim of this longitudinal cohort study is to compare knee joint structural features on MRI and knee symptoms at baseline and 4-year follow-up in runners with and without a history of knee surgery. Secondary aims are to explore the relationships between training load exposures (volume and/or intensity) and changes in knee joint structure and symptoms over 4 years; explore the relationship between baseline running biomechanics, and changes in knee joint structure and symptoms over 4 years. In addition, we will explore whether ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-27T02:30:55.018Z","creation":"2025-04-06T18:38:44.208Z"},"accession":"S-EPMC9923264","cross_references":{"pubmed":["36759025"],"doi":["10.1136/bmjopen-2022-068040"]}}