biostudies-literatureUnknown38(2)Levin ASwedish Kidney FoundationThe Stig and Gunborg Westman FoundationStockholm County Council<h4>Background</h4>Immunoglobulin A nephropathy (IgAN) and its systemic variant IgA vasculitis (IgAV) damage the glomeruli, resulting in proteinuria, hematuria and kidney impairment. Dendrin is a podocyte-specific protein suggested to be involved in the pathogenesis of IgAN. Upon cell injury, dendrin translocates from the slit diaphragm to the nucleus, where it is suggested to induce apoptosis and cytoskeletal changes, resulting in proteinuria and accelerated disease progression in mice. Here we investigated gene and protein expression of dendrin in relation to clinical and histopathological findings to further elucidate its role in IgAN/IgAV.<h4>Methods</h4>Glomerular gene expression was measured using microarray on 30 IgAN/IgAV patients, 5 patients with membranous nephropathy (MN) and 20Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association311-321https://www.ebi.ac.uk/biostudies/studies/S-EPMC9923709biostudies-literatureThe role of dendrin in IgA nephropathy.PMC9923709Levin ASchwarz AMolne JHerthelius MEbefors KHe LSun YWitasp ANystrom JWernerson AWennberg LBarany PHulkko JPatrakka JHultenby KBruchfeld ABetsholtz CfalseThe role of dendrin in IgA nephropathy.<h4>Background</h4>Immunoglobulin A nephropathy (IgAN) and its systemic variant IgA vasculitis (IgAV) damage the glomeruli, resulting in proteinuria, hematuria and kidney impairment. Dendrin is a podocyte-specific protein suggested to be involved in the pathogenesis of IgAN. Upon cell injury, dendrin translocates from the slit diaphragm to the nucleus, where it is suggested to induce apoptosis and cytoskeletal changes, resulting in proteinuria and accelerated disease progression in mice. Here we investigated gene and protein expression of dendrin in relation to clinical and histopathological findings to further elucidate its role in IgAN/IgAV.<h4>Methods</h4>Glomerular gene expression was measured using microarray on 30 IgAN/IgAV patients, 5 patients with membranous nephropathy (MN) and 202023-01-01T00:00:00Z2023 Feb2025-04-04T12:43:05.538Z2025-04-04T12:43:05.538ZS-EPMC99237093576785210.1093/ndt/gfac208