biostudies-literatureSuo XMedical Research CouncilChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaSichuan University4857-4868https://www.ebi.ac.uk/biostudies/studies/S-EPMC9923713biostudies-literatureUnknown32(21)Mild cognitive impairment in Parkinson's disease (PD-M) is related to a high risk of dementia. This study explored the whole-brain functional networks in early-stage PD-M. Forty-one patients with PD classified as cognitively normal (PD-N, n = 17) and PD-M (n = 24) and 24 demographically matched healthy controls (HC) underwent clinical and neuropsychological evaluations and resting-state functional magnetic resonance imaging. The global, regional, and modular topological characteristics were assessed in the brain functional networks, and their relationships to cognitive scores were tested. At the global level, PD-M and PD-N exhibited higher characteristic path length and lower clustering coefficient, local and global efficiency relative to HC. At the regional level, PD-M and PD-N showed lowCerebral cortex (New York, N.Y. : 1991)Brain functional network abnormalities in parkinson's disease with mild cognitive impairment.PMC9923713MR/P020941/12019HXBH10481820108018816210032021-YF05-01587-SN8202780822MZGC0308820018002020 M683317Li WGong QKemp GJPeng RQin KLei DChen CSuo XPeng JLi NfalseBrain functional network abnormalities in parkinson's disease with mild cognitive impairment.Mild cognitive impairment in Parkinson's disease (PD-M) is related to a high risk of dementia. This study explored the whole-brain functional networks in early-stage PD-M. Forty-one patients with PD classified as cognitively normal (PD-N, n = 17) and PD-M (n = 24) and 24 demographically matched healthy controls (HC) underwent clinical and neuropsychological evaluations and resting-state functional magnetic resonance imaging. The global, regional, and modular topological characteristics were assessed in the brain functional networks, and their relationships to cognitive scores were tested. At the global level, PD-M and PD-N exhibited higher characteristic path length and lower clustering coefficient, local and global efficiency relative to HC. At the regional level, PD-M and PD-N showed low2022-01-01T00:00:00Z2022 Oct2026-03-31T11:00:06.43Z2025-04-07T09:23:39.258ZS-EPMC99237133507820910.1093/cercor/bhab520