{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Panda SP"],"pubmed_abstract":["<i><b>Introduction:</b> </i> The mixed flavonoid supplement (MFS) [Trimethoxy Flavones (TMF) + epigallocatechin-3-gallate (EGCG)] can be used to suppress inflammatory ulcers as an ethical medicine in Ayurveda. The inflammation of the rectum and anal regions is mostly attributed to nuclear factor kappa beta (NF-κB) signaling. NF-κB stimulates the expression of matrix metalloproteinase (MMP9), inflammatory cytokines tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β). Although much research targeted the NF-κB and MMP9 signaling pathways, a subsequent investigation of target mediators in the inflammatory ulcer healing and NF-κB pathway has not been done. <i><b>Methods:</b> </i> The docking studies of compounds TMF and EGCG were performed by applying PyRx and available software to unders"],"journal":["BioImpacts : BI"],"pagination":["73-84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9923810"],"repository":["biostudies-literature"],"pubmed_title":["Inhibitory effects of mixed flavonoid supplements on unraveled DSS-induced ulcerative colitis and arthritis."],"pmcid":["PMC9923810"],"pubmed_authors":["Mahamat MSA","Jena BR","Abasher MAA","Ismail IA","Prasanth D","Rasool MA","Panda SP"],"additional_accession":[]},"is_claimable":false,"name":"Inhibitory effects of mixed flavonoid supplements on unraveled DSS-induced ulcerative colitis and arthritis.","description":"<i><b>Introduction:</b> </i> The mixed flavonoid supplement (MFS) [Trimethoxy Flavones (TMF) + epigallocatechin-3-gallate (EGCG)] can be used to suppress inflammatory ulcers as an ethical medicine in Ayurveda. The inflammation of the rectum and anal regions is mostly attributed to nuclear factor kappa beta (NF-κB) signaling. NF-κB stimulates the expression of matrix metalloproteinase (MMP9), inflammatory cytokines tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β). Although much research targeted the NF-κB and MMP9 signaling pathways, a subsequent investigation of target mediators in the inflammatory ulcer healing and NF-κB pathway has not been done. <i><b>Methods:</b> </i> The docking studies of compounds TMF and EGCG were performed by applying PyRx and available software to unders","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T20:52:35.596Z","creation":"2024-11-20T20:32:51.581Z"},"accession":"S-EPMC9923810","cross_references":{"pubmed":["36817000"],"doi":["10.34172/bi.2022.23523"]}}