biostudies-literatureUnknown13(1)Panda SP<i><b>Introduction:</b> </i> The mixed flavonoid supplement (MFS) [Trimethoxy Flavones (TMF) + epigallocatechin-3-gallate (EGCG)] can be used to suppress inflammatory ulcers as an ethical medicine in Ayurveda. The inflammation of the rectum and anal regions is mostly attributed to nuclear factor kappa beta (NF-κB) signaling. NF-κB stimulates the expression of matrix metalloproteinase (MMP9), inflammatory cytokines tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β). Although much research targeted the NF-κB and MMP9 signaling pathways, a subsequent investigation of target mediators in the inflammatory ulcer healing and NF-κB pathway has not been done. <i><b>Methods:</b> </i> The docking studies of compounds TMF and EGCG were performed by applying PyRx and available software to undersBioImpacts : BI73-84https://www.ebi.ac.uk/biostudies/studies/S-EPMC9923810biostudies-literatureInhibitory effects of mixed flavonoid supplements on unraveled DSS-induced ulcerative colitis and arthritis.PMC9923810Mahamat MSAJena BRAbasher MAAIsmail IAPrasanth DRasool MAPanda SPfalseInhibitory effects of mixed flavonoid supplements on unraveled DSS-induced ulcerative colitis and arthritis.<i><b>Introduction:</b> </i> The mixed flavonoid supplement (MFS) [Trimethoxy Flavones (TMF) + epigallocatechin-3-gallate (EGCG)] can be used to suppress inflammatory ulcers as an ethical medicine in Ayurveda. The inflammation of the rectum and anal regions is mostly attributed to nuclear factor kappa beta (NF-κB) signaling. NF-κB stimulates the expression of matrix metalloproteinase (MMP9), inflammatory cytokines tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β). Although much research targeted the NF-κB and MMP9 signaling pathways, a subsequent investigation of target mediators in the inflammatory ulcer healing and NF-κB pathway has not been done. <i><b>Methods:</b> </i> The docking studies of compounds TMF and EGCG were performed by applying PyRx and available software to unders2023-01-01T00:00:00Z20232025-04-04T20:52:35.596Z2024-11-20T20:32:51.581ZS-EPMC99238103681700010.34172/bi.2022.23523