biostudies-literatureWang SNICHD NIH HHSNIEHS NIH HHSNHLBI NIH HHSNCI NIH HHSNational Institutes of HealthNIH HHS4022-4031https://www.ebi.ac.uk/biostudies/studies/S-EPMC9924056biostudies-literatureUnknown53(9)<h4>Background</h4>Pre-pandemic psychological distress is associated with increased susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but associations with the coronavirus disease 2019 (COVID-19) severity are not established. The authors examined the associations between distress prior to SARS-CoV-2 infection and subsequent risk of hospitalization.<h4>Methods</h4>Between April 2020 (baseline) and April 2021, we followed 54 781 participants from three ongoing cohorts: Nurses' Health Study II (NHSII), Nurses' Health Study 3 (NHS3), and the Growing Up Today Study (GUTS) who reported no current or prior SARS-CoV-2 infection at baseline. Chronic depression was assessed during 2010-2019. Depression, anxiety, worry about COVID-19, perceived stress, and lonePsychological medicineDepression, worry, and loneliness are associated with subsequent risk of hospitalization for COVID-19: a prospective study.PMC9924056grants U01HL145386, R24ES028521, U01 CA176726, R01 CA67262, and R01 HD057368R01 HD057368U01 HL145386U01 CA176726R24 ES028521R01 CA067262R01 HD094725Roberts ALChavarro JEKubzansky LDBranch-Elliman WWang SKang JHKoenen KCQuan LDing MfalseDepression, worry, and loneliness are associated with subsequent risk of hospitalization for COVID-19: a prospective study.<h4>Background</h4>Pre-pandemic psychological distress is associated with increased susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but associations with the coronavirus disease 2019 (COVID-19) severity are not established. The authors examined the associations between distress prior to SARS-CoV-2 infection and subsequent risk of hospitalization.<h4>Methods</h4>Between April 2020 (baseline) and April 2021, we followed 54 781 participants from three ongoing cohorts: Nurses' Health Study II (NHSII), Nurses' Health Study 3 (NHS3), and the Growing Up Today Study (GUTS) who reported no current or prior SARS-CoV-2 infection at baseline. Chronic depression was assessed during 2010-2019. Depression, anxiety, worry about COVID-19, perceived stress, and lone2023-01-01T00:00:00Z2023 Jul2025-04-04T03:01:03.026Z2024-11-19T20:42:10.635ZS-EPMC99240563558690610.1017/s003329172200069110.1017/S0033291722000691