{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Murthy BKB"],"pubmed_abstract":["Subpopulations of neurons display increased activity during memory encoding and manipulating the activity of these neurons can induce artificial formation or erasure of memories. Thus, these neurons are thought to be cellular engrams. Moreover, correlated activity between pre- and postsynaptic engram neurons is thought to lead to strengthening of their synaptic connections, thus increasing the probability of neural activity patterns occurring during encoding to reoccur at recall. Therefore, synapses between engram neurons can also be considered as a substrate of memory, or a synaptic engram. One can label synaptic engrams by targeting two complementary, non-fluorescent, synapse-targeted GFP fragments separately to the pre- and postsynaptic compartment of engram neurons; the two GFP fragmen"],"journal":["Frontiers in behavioral neuroscience"],"pagination":["1072571"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9924068"],"repository":["biostudies-literature"],"pubmed_title":["Arc-driven mGRASP highlights CA1 to CA3 synaptic engrams."],"pmcid":["PMC9924068"],"pubmed_authors":["Ulivi AF","Chen A","Murthy BKB","Haynes N","Attardo A","Somatakis S","Castello-Waldow TP","Huettl RE","Klimmt H"],"additional_accession":[]},"is_claimable":false,"name":"Arc-driven mGRASP highlights CA1 to CA3 synaptic engrams.","description":"Subpopulations of neurons display increased activity during memory encoding and manipulating the activity of these neurons can induce artificial formation or erasure of memories. Thus, these neurons are thought to be cellular engrams. Moreover, correlated activity between pre- and postsynaptic engram neurons is thought to lead to strengthening of their synaptic connections, thus increasing the probability of neural activity patterns occurring during encoding to reoccur at recall. Therefore, synapses between engram neurons can also be considered as a substrate of memory, or a synaptic engram. One can label synaptic engrams by targeting two complementary, non-fluorescent, synapse-targeted GFP fragments separately to the pre- and postsynaptic compartment of engram neurons; the two GFP fragmen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T10:36:21.737Z","creation":"2025-04-05T10:36:21.737Z"},"accession":"S-EPMC9924068","cross_references":{"pubmed":["36793796"],"doi":["10.3389/fnbeh.2022.1072571"]}}