biostudies-literatureUnknown42(4)Ziyi Z<h4>Objective</h4>To investigate the short-term efficacy and safety outcomes following a sequential treatment with clearing heat and eliminating phlegm (CHEP) formula and tonifying Qi and activating blood circulation (TQABC) formula in patients with acute ischemic stroke (AIS) within a 72 h time window.<h4>Methods</h4>In this randomized, multicenter, double-blinded, placebo-controlled trial, 500 participants will be randomly assigned in a ratio of 1∶1 to the CHEP+ TQABC group or control group. In addition to guideline-based standard medical care, participants in the treatment group will receive the CHEP formula for the first 5 consecutive days followed by the TQABC formula for another 10 consecutive days, while those in the control group will receive CHEP formula placebo and TQABC formula Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan604-610https://www.ebi.ac.uk/biostudies/studies/S-EPMC9924680biostudies-literatureEfficacy and safety of a sequential treatment with clearing heat and eliminating phlegm and tonifying and activating blood circulation in treating acute ischemic stroke: study protocol for a randomized controlled trial.PMC9924680Lejun LIXiangzhe LYefeng CMingzhe HUYing GChunhua WZiyi ZJie CYuanqi ZHuili ZXiaofei YUHongwei ANQing SCan WXinchun ZWenguo HHuijuan WJunbin CfalseEfficacy and safety of a sequential treatment with clearing heat and eliminating phlegm and tonifying and activating blood circulation in treating acute ischemic stroke: study protocol for a randomized controlled trial.<h4>Objective</h4>To investigate the short-term efficacy and safety outcomes following a sequential treatment with clearing heat and eliminating phlegm (CHEP) formula and tonifying Qi and activating blood circulation (TQABC) formula in patients with acute ischemic stroke (AIS) within a 72 h time window.<h4>Methods</h4>In this randomized, multicenter, double-blinded, placebo-controlled trial, 500 participants will be randomly assigned in a ratio of 1∶1 to the CHEP+ TQABC group or control group. In addition to guideline-based standard medical care, participants in the treatment group will receive the CHEP formula for the first 5 consecutive days followed by the TQABC formula for another 10 consecutive days, while those in the control group will receive CHEP formula placebo and TQABC formula 2022-01-01T00:00:00Z2022 Aug2025-04-04T14:24:21.041Z2024-11-12T18:11:28.826ZS-EPMC99246803584897710.19852/j.cnki.jtcm.20220617.003