{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Curot J"],"funding":["European Union’s Seventh Framework Programme","International Development Research Centre, Canada","Fondation Française pour la Recherche sur l'Epilepsie","Canada-Israel Health Research Initiative","Canada Brain Research Fund","Canadian Institutes of Health Research","CIHR","Fondation Française pour la Recherche sur l’Epilepsie","European Research Council","Azrieli Foundation","European Union's Seventh Framework Programme","Israel Science Foundation","NSERC Discovery","CIHR Project"],"pagination":["561-575"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9924905"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["146(2)"],"pubmed_abstract":["Understanding the neuronal basis of epileptic activity is a major challenge in neurology. Cellular integration into larger scale networks is all the more challenging. In the local field potential, interictal epileptic discharges can be associated with fast ripples (200-600 Hz), which are a promising marker of the epileptogenic zone. Yet, how neuronal populations in the epileptogenic zone and in healthy tissue are affected by fast ripples remain unclear. Here, we used a novel 'hybrid' macro-micro depth electrode in nine drug-resistant epileptic patients, combining classic depth recording of local field potentials (macro-contacts) and two or three tetrodes (four micro-wires bundled together) enabling up to 15 neurons in local circuits to be simultaneously recorded. We characterized neuronal "],"journal":["Brain : a journal of neurology"],"pubmed_title":["Local neuronal excitation and global inhibition during epileptic fast ripples in humans."],"pmcid":["PMC9924905"],"funding_grant_id":["FP/2007-2013","RGPIN-2018-04600","108877-001","155957","323711"],"pubmed_authors":["Lotterie JA","Despouy E","Sol JC","Barbeau E","Curot J","Valton L","Denuelle M","Peyrache A"],"additional_accession":[]},"is_claimable":false,"name":"Local neuronal excitation and global inhibition during epileptic fast ripples in humans.","description":"Understanding the neuronal basis of epileptic activity is a major challenge in neurology. Cellular integration into larger scale networks is all the more challenging. In the local field potential, interictal epileptic discharges can be associated with fast ripples (200-600 Hz), which are a promising marker of the epileptogenic zone. Yet, how neuronal populations in the epileptogenic zone and in healthy tissue are affected by fast ripples remain unclear. Here, we used a novel 'hybrid' macro-micro depth electrode in nine drug-resistant epileptic patients, combining classic depth recording of local field potentials (macro-contacts) and two or three tetrodes (four micro-wires bundled together) enabling up to 15 neurons in local circuits to be simultaneously recorded. We characterized neuronal ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-18T21:29:35.724Z","creation":"2025-04-07T09:20:58.809Z"},"accession":"S-EPMC9924905","cross_references":{"pubmed":["36093747"],"doi":["10.1093/brain/awac319"]}}