biostudies-literatureCurot JEuropean Union’s Seventh Framework ProgrammeInternational Development Research Centre, CanadaFondation Française pour la Recherche sur l'EpilepsieCanada-Israel Health Research InitiativeCanada Brain Research FundCanadian Institutes of Health ResearchCIHRFondation Française pour la Recherche sur l’EpilepsieEuropean Research CouncilAzrieli FoundationEuropean Union's Seventh Framework ProgrammeIsrael Science FoundationNSERC DiscoveryCIHR Project561-575https://www.ebi.ac.uk/biostudies/studies/S-EPMC9924905biostudies-literatureUnknown146(2)Understanding the neuronal basis of epileptic activity is a major challenge in neurology. Cellular integration into larger scale networks is all the more challenging. In the local field potential, interictal epileptic discharges can be associated with fast ripples (200-600 Hz), which are a promising marker of the epileptogenic zone. Yet, how neuronal populations in the epileptogenic zone and in healthy tissue are affected by fast ripples remain unclear. Here, we used a novel 'hybrid' macro-micro depth electrode in nine drug-resistant epileptic patients, combining classic depth recording of local field potentials (macro-contacts) and two or three tetrodes (four micro-wires bundled together) enabling up to 15 neurons in local circuits to be simultaneously recorded. We characterized neuronal Brain : a journal of neurologyLocal neuronal excitation and global inhibition during epileptic fast ripples in humans.PMC9924905FP/2007-2013RGPIN-2018-04600108877-001155957323711Lotterie JADespouy ESol JCBarbeau ECurot JValton LDenuelle MPeyrache AfalseLocal neuronal excitation and global inhibition during epileptic fast ripples in humans.Understanding the neuronal basis of epileptic activity is a major challenge in neurology. Cellular integration into larger scale networks is all the more challenging. In the local field potential, interictal epileptic discharges can be associated with fast ripples (200-600 Hz), which are a promising marker of the epileptogenic zone. Yet, how neuronal populations in the epileptogenic zone and in healthy tissue are affected by fast ripples remain unclear. Here, we used a novel 'hybrid' macro-micro depth electrode in nine drug-resistant epileptic patients, combining classic depth recording of local field potentials (macro-contacts) and two or three tetrodes (four micro-wires bundled together) enabling up to 15 neurons in local circuits to be simultaneously recorded. We characterized neuronal 2023-01-01T00:00:00Z2023 Feb2025-04-18T21:29:35.724Z2025-04-07T09:20:58.809ZS-EPMC99249053609374710.1093/brain/awac319