biostudies-literatureUnknown13(3)Li RQWhile psychological factors have long been linked to breast cancer pathogenesis and outcomes, accumulating evidence is revealing how the nervous system contributes to breast cancer development, progression, and treatment resistance. Central to the psychological-neurological nexus are interactions between neurotransmitters and their receptors expressed on breast cancer cells and other types of cells in the tumor microenvironment, which activate various intracellular signaling pathways. Importantly, the manipulation of these interactions is emerging as a potential avenue for breast cancer prevention and treatment. However, an important caveat is that the same neurotransmitter can exert multiple and sometimes opposing effects. In addition, certain neurotransmitters can be produced and secreteTheranostics1109-1129https://www.ebi.ac.uk/biostudies/studies/S-EPMC9925324biostudies-literatureExploring neurotransmitters and their receptors for breast cancer prevention and treatment.PMC9925324Thorne RFZhang XDZhao XHHondermarck HLiu TLi RQZhu QGao JNfalseExploring neurotransmitters and their receptors for breast cancer prevention and treatment.While psychological factors have long been linked to breast cancer pathogenesis and outcomes, accumulating evidence is revealing how the nervous system contributes to breast cancer development, progression, and treatment resistance. Central to the psychological-neurological nexus are interactions between neurotransmitters and their receptors expressed on breast cancer cells and other types of cells in the tumor microenvironment, which activate various intracellular signaling pathways. Importantly, the manipulation of these interactions is emerging as a potential avenue for breast cancer prevention and treatment. However, an important caveat is that the same neurotransmitter can exert multiple and sometimes opposing effects. In addition, certain neurotransmitters can be produced and secrete2023-01-01T00:00:00Z20232025-06-01T02:31:55.407Z2024-11-15T08:06:04.659ZS-EPMC99253243679386910.7150/thno.81403