biostudies-literatureUnknown116(4)Philippe AAgence Nationale de la RechercheFondation de France<h4>Background</h4>Coronavirus disease 2019 (COVID-19) is associated with an inflammatory cytokine burst and a prothrombotic coagulopathy. Platelets may contribute to microthrombosis, and constitute a therapeutic target in COVID-19 therapy.<h4>Aim</h4>To assess if platelet activation influences mortality in COVID-19.<h4>Methods</h4>We explored two cohorts of patients with COVID-19. Cohort A included 208 ambulatory and hospitalized patients with varying clinical severities and non-COVID patients as controls, in whom plasma concentrations of the soluble platelet activation biomarkers CD40 ligand (sCD40L) and P-selectin (sP-sel) were quantified within the first 48hours following hospitalization. Cohort B was a multicentre cohort of 2878 patients initially admitted to a medical ward. In both cArchives of cardiovascular diseases183-191https://www.ebi.ac.uk/biostudies/studies/S-EPMC9925415biostudies-literaturePlatelet activation and coronavirus disease 2019 mortality: Insights from coagulopathy, antiplatelet therapy and inflammation.PMC9925415Sanchez OFauvel CPlanquette BMirault TSmadja DMWeizman OChocron RSamama CMPhilippe AWaldmann VCohen AGaussem PHadjadj JGuerin CLGendron NTerrier BBonnet GHauw-Berlemont CFontenay MSutter WYatim NDiehl JLfalsePlatelet activation and coronavirus disease 2019 mortality: Insights from coagulopathy, antiplatelet therapy and inflammation.<h4>Background</h4>Coronavirus disease 2019 (COVID-19) is associated with an inflammatory cytokine burst and a prothrombotic coagulopathy. Platelets may contribute to microthrombosis, and constitute a therapeutic target in COVID-19 therapy.<h4>Aim</h4>To assess if platelet activation influences mortality in COVID-19.<h4>Methods</h4>We explored two cohorts of patients with COVID-19. Cohort A included 208 ambulatory and hospitalized patients with varying clinical severities and non-COVID patients as controls, in whom plasma concentrations of the soluble platelet activation biomarkers CD40 ligand (sCD40L) and P-selectin (sP-sel) were quantified within the first 48hours following hospitalization. Cohort B was a multicentre cohort of 2878 patients initially admitted to a medical ward. In both c2023-01-01T00:00:00Z2023 Apr2025-04-05T11:43:37.792Z2025-02-18T22:34:12.25ZS-EPMC99254153685890910.1016/j.acvd.2023.01.006