{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tseng TC"],"funding":["National Taiwan University Hospital","Ministry of Science and Technology, Taiwan","Ministry of Health and Welfare"],"pagination":["589-606"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9925660"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["<h4>Introduction</h4>High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE. However, clinical studies comparing daptomycin monotherapy with daptomycin/fosfomycin combinations are unavailable.<h4>Methods</h4>An observational study of VRE-BSI was performed between 2010-2021 on patients receiving daptomycin monotherapy (≥ 8 mg/kg) or daptomycin combined with intravenous fosfomycin. Patients treated with concomitant β-lactam combinations were excluded. The primary outcome was in-hospital mortality. Outcomes were analyzed using multivariable logistic regression and augmented inverse probability weighting (AIPW) analyses.<h4"],"journal":["Infectious diseases and therapy"],"pubmed_title":["The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study."],"pmcid":["PMC9925660"],"funding_grant_id":["NTUH. 110-S4901","111-2314-B-002-209","110-2326-B-002-003-MY3","110-2628-B-002-059","MOHW111-TDU-B-211-134002"],"pubmed_authors":["Chang SC","Tseng TC","Wang JT","Chen YC","Huang SH","Chuang YC","Yang JL","Lin CY"],"additional_accession":[]},"is_claimable":false,"name":"The Combination of Daptomycin with Fosfomycin is More Effective than Daptomycin Alone in Reducing Mortality of Vancomycin-Resistant Enterococcal Bloodstream Infections: A Retrospective, Comparative Cohort Study.","description":"<h4>Introduction</h4>High-dose daptomycin-based combinations are recommended for vancomycin-resistant Enterococcus (VRE) bloodstream infection (BSI). Preclinical data have shown a synergistic effect of daptomycin/fosfomycin combinations against VRE. However, clinical studies comparing daptomycin monotherapy with daptomycin/fosfomycin combinations are unavailable.<h4>Methods</h4>An observational study of VRE-BSI was performed between 2010-2021 on patients receiving daptomycin monotherapy (≥ 8 mg/kg) or daptomycin combined with intravenous fosfomycin. Patients treated with concomitant β-lactam combinations were excluded. The primary outcome was in-hospital mortality. Outcomes were analyzed using multivariable logistic regression and augmented inverse probability weighting (AIPW) analyses.<h4","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T12:41:50.811Z","creation":"2025-04-04T12:41:50.811Z"},"accession":"S-EPMC9925660","cross_references":{"pubmed":["36629997"],"doi":["10.1007/s40121-022-00754-1"]}}