{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(2)"],"submitter":["Jiang G"],"pubmed_abstract":["<h4>Objective</h4>This study was performed to explore the prognostic relevance of <i>structural maintenance of chromosomes 4</i> (<i>SMC4</i>) in pan-cancer and explore the association between <i>SMC4</i> and immune infiltration of sarcoma.<h4>Results</h4>Elevated expression of <i>SMC4</i> was detected in cancer tissues compared to normal tissue, which was confirmed in synovial sarcoma tissues with immunohistochemistry (IHC). Additionally, higher expression of <i>SMC4</i> was connected to worse outcomes of sarcoma, gastric cancer, breast cancer, liver cancer or ovarian cancer. Moreover, <i>SMC4</i> was positively connected to immune cell infiltrates in sarcoma. In addition, infiltrating immune cell markers including monocyte, TAM, M1 and M2 presented different <i>SMC4</i>-associated immune"],"journal":["Aging"],"pagination":["567-582"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9925680"],"repository":["biostudies-literature"],"pubmed_title":["Association of <i>SMC4</i> with prognosis and immune infiltration of sarcoma."],"pmcid":["PMC9925680"],"pubmed_authors":["Li Y","Chen J","Jiang G","Zhang Y","Wang W","Wu G","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Association of <i>SMC4</i> with prognosis and immune infiltration of sarcoma.","description":"<h4>Objective</h4>This study was performed to explore the prognostic relevance of <i>structural maintenance of chromosomes 4</i> (<i>SMC4</i>) in pan-cancer and explore the association between <i>SMC4</i> and immune infiltration of sarcoma.<h4>Results</h4>Elevated expression of <i>SMC4</i> was detected in cancer tissues compared to normal tissue, which was confirmed in synovial sarcoma tissues with immunohistochemistry (IHC). Additionally, higher expression of <i>SMC4</i> was connected to worse outcomes of sarcoma, gastric cancer, breast cancer, liver cancer or ovarian cancer. Moreover, <i>SMC4</i> was positively connected to immune cell infiltrates in sarcoma. In addition, infiltrating immune cell markers including monocyte, TAM, M1 and M2 presented different <i>SMC4</i>-associated immune","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-22T20:01:36.253Z","creation":"2025-04-06T02:57:00.47Z"},"accession":"S-EPMC9925680","cross_references":{"pubmed":["36719264"],"doi":["10.18632/aging.204503"]}}