biostudies-literatureUnknown15(2)Jiang G<h4>Objective</h4>This study was performed to explore the prognostic relevance of <i>structural maintenance of chromosomes 4</i> (<i>SMC4</i>) in pan-cancer and explore the association between <i>SMC4</i> and immune infiltration of sarcoma.<h4>Results</h4>Elevated expression of <i>SMC4</i> was detected in cancer tissues compared to normal tissue, which was confirmed in synovial sarcoma tissues with immunohistochemistry (IHC). Additionally, higher expression of <i>SMC4</i> was connected to worse outcomes of sarcoma, gastric cancer, breast cancer, liver cancer or ovarian cancer. Moreover, <i>SMC4</i> was positively connected to immune cell infiltrates in sarcoma. In addition, infiltrating immune cell markers including monocyte, TAM, M1 and M2 presented different <i>SMC4</i>-associated immuneAging567-582https://www.ebi.ac.uk/biostudies/studies/S-EPMC9925680biostudies-literatureAssociation of <i>SMC4</i> with prognosis and immune infiltration of sarcoma.PMC9925680Li YChen JJiang GZhang YWang WWu GZhou JfalseAssociation of <i>SMC4</i> with prognosis and immune infiltration of sarcoma.<h4>Objective</h4>This study was performed to explore the prognostic relevance of <i>structural maintenance of chromosomes 4</i> (<i>SMC4</i>) in pan-cancer and explore the association between <i>SMC4</i> and immune infiltration of sarcoma.<h4>Results</h4>Elevated expression of <i>SMC4</i> was detected in cancer tissues compared to normal tissue, which was confirmed in synovial sarcoma tissues with immunohistochemistry (IHC). Additionally, higher expression of <i>SMC4</i> was connected to worse outcomes of sarcoma, gastric cancer, breast cancer, liver cancer or ovarian cancer. Moreover, <i>SMC4</i> was positively connected to immune cell infiltrates in sarcoma. In addition, infiltrating immune cell markers including monocyte, TAM, M1 and M2 presented different <i>SMC4</i>-associated immune2023-01-01T00:00:00Z2023 Jan2025-04-22T20:01:36.253Z2025-04-06T02:57:00.47ZS-EPMC99256803671926410.18632/aging.204503