biostudies-literatureGiongo FKFundo de Incentivo à Pesquisa e Eventos do Hospital de Clínicas de Porto AlegreFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul125-136https://www.ebi.ac.uk/biostudies/studies/S-EPMC9926054biostudies-literatureUnknown26(2)<h4>Background</h4>Altered redox state and developmental abnormalities in glutamatergic and GABAergic transmission during development are linked to the behavioral changes associated with schizophrenia. As an amino acid that exerts antioxidant and inhibitory actions in the brain, taurine is a potential candidate to modulate biological targets relevant to this disorder. Here, we investigated in mice and zebrafish assays whether taurine prevents the behavioral changes induced by acute administration of MK-801 (dizocilpine), a glutamate N-methyl-D-aspartate (NMDA) receptor antagonist.<h4>Methods</h4>C57BL/6 mice were i.p. administered with saline or taurine (50, 100, and 200 mg/kg) followed by MK-801 (0.15 mg/kg). Locomotor activity, social interaction, and prepulse inhibition of the acoustic The international journal of neuropsychopharmacologyEffects of Taurine in Mice and Zebrafish Behavioral Assays With Translational Relevance to Schizophrenia.PMC992605419/2551-0001216-02018-0498Giongo FKHerrmann APSachett ABastos LMRosa ARGallas-Lopes MBenvenutti RfalseEffects of Taurine in Mice and Zebrafish Behavioral Assays With Translational Relevance to Schizophrenia.<h4>Background</h4>Altered redox state and developmental abnormalities in glutamatergic and GABAergic transmission during development are linked to the behavioral changes associated with schizophrenia. As an amino acid that exerts antioxidant and inhibitory actions in the brain, taurine is a potential candidate to modulate biological targets relevant to this disorder. Here, we investigated in mice and zebrafish assays whether taurine prevents the behavioral changes induced by acute administration of MK-801 (dizocilpine), a glutamate N-methyl-D-aspartate (NMDA) receptor antagonist.<h4>Methods</h4>C57BL/6 mice were i.p. administered with saline or taurine (50, 100, and 200 mg/kg) followed by MK-801 (0.15 mg/kg). Locomotor activity, social interaction, and prepulse inhibition of the acoustic 2023-01-01T00:00:00Z2023 Feb2025-04-18T12:44:32.127Z2024-10-16T19:10:08.62ZS-EPMC99260543623945510.1093/ijnp/pyac073