{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(2)"],"submitter":["Dong R"],"pubmed_abstract":["<h4>Objective</h4>To evaluate the recent practice of design and statistical analysis of ophthalmic randomized clinical trials (RCTs).<h4>Design</h4>Review of 96 ophthalmic RCTs.<h4>Methods</h4>Two authors (R.D., G.S.Y.) reviewed primary result papers published from January 2020 through December 2021 in <i>Ophthalmology</i>, <i>JAMA Ophthalmology</i>, <i>American Journal of Ophthalmology</i>, and <i>British Journal of Ophthalmology</i>. Data were extracted and analyzed for the characteristics of design (1-eye design, 2-eye design, paired-eye design, and subject design), sample size and power, and statistical analysis for intereye correlation adjustment, missing data, and correction for multiplicity.<h4>Main outcome measures</h4>Characteristics of trial design and statistical analysis.<h4>Re"],"journal":["Ophthalmology science"],"pagination":["100266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9926296"],"repository":["biostudies-literature"],"pubmed_title":["Characteristics of Design and Analysis of Ophthalmic Randomized Controlled Trials: A Review of Ophthalmic Papers 2020-2021."],"pmcid":["PMC9926296"],"pubmed_authors":["Ying GS","Dong R"],"additional_accession":[]},"is_claimable":false,"name":"Characteristics of Design and Analysis of Ophthalmic Randomized Controlled Trials: A Review of Ophthalmic Papers 2020-2021.","description":"<h4>Objective</h4>To evaluate the recent practice of design and statistical analysis of ophthalmic randomized clinical trials (RCTs).<h4>Design</h4>Review of 96 ophthalmic RCTs.<h4>Methods</h4>Two authors (R.D., G.S.Y.) reviewed primary result papers published from January 2020 through December 2021 in <i>Ophthalmology</i>, <i>JAMA Ophthalmology</i>, <i>American Journal of Ophthalmology</i>, and <i>British Journal of Ophthalmology</i>. Data were extracted and analyzed for the characteristics of design (1-eye design, 2-eye design, paired-eye design, and subject design), sample size and power, and statistical analysis for intereye correlation adjustment, missing data, and correction for multiplicity.<h4>Main outcome measures</h4>Characteristics of trial design and statistical analysis.<h4>Re","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-05-29T19:59:51.216Z","creation":"2024-11-06T12:47:49.582Z"},"accession":"S-EPMC9926296","cross_references":{"pubmed":["36798523"],"doi":["10.1016/j.xops.2022.100266"]}}