biostudies-literatureUnknown3(2)Dong R<h4>Objective</h4>To evaluate the recent practice of design and statistical analysis of ophthalmic randomized clinical trials (RCTs).<h4>Design</h4>Review of 96 ophthalmic RCTs.<h4>Methods</h4>Two authors (R.D., G.S.Y.) reviewed primary result papers published from January 2020 through December 2021 in <i>Ophthalmology</i>, <i>JAMA Ophthalmology</i>, <i>American Journal of Ophthalmology</i>, and <i>British Journal of Ophthalmology</i>. Data were extracted and analyzed for the characteristics of design (1-eye design, 2-eye design, paired-eye design, and subject design), sample size and power, and statistical analysis for intereye correlation adjustment, missing data, and correction for multiplicity.<h4>Main outcome measures</h4>Characteristics of trial design and statistical analysis.<h4>ReOphthalmology science100266https://www.ebi.ac.uk/biostudies/studies/S-EPMC9926296biostudies-literatureCharacteristics of Design and Analysis of Ophthalmic Randomized Controlled Trials: A Review of Ophthalmic Papers 2020-2021.PMC9926296Ying GSDong RfalseCharacteristics of Design and Analysis of Ophthalmic Randomized Controlled Trials: A Review of Ophthalmic Papers 2020-2021.<h4>Objective</h4>To evaluate the recent practice of design and statistical analysis of ophthalmic randomized clinical trials (RCTs).<h4>Design</h4>Review of 96 ophthalmic RCTs.<h4>Methods</h4>Two authors (R.D., G.S.Y.) reviewed primary result papers published from January 2020 through December 2021 in <i>Ophthalmology</i>, <i>JAMA Ophthalmology</i>, <i>American Journal of Ophthalmology</i>, and <i>British Journal of Ophthalmology</i>. Data were extracted and analyzed for the characteristics of design (1-eye design, 2-eye design, paired-eye design, and subject design), sample size and power, and statistical analysis for intereye correlation adjustment, missing data, and correction for multiplicity.<h4>Main outcome measures</h4>Characteristics of trial design and statistical analysis.<h4>Re2023-01-01T00:00:00Z2023 Jun2025-05-29T19:59:51.216Z2024-11-06T12:47:49.582ZS-EPMC99262963679852310.1016/j.xops.2022.100266