{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma C"],"funding":["Program of Shanghai Academic Research Leader","National Natural Science Foundation of China"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9926673"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>N<sup>7</sup>-methylguanosine (m<sup>7</sup>G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment in heart failure (HF).<h4>Results</h4>One hundred twenty-four HF patients and 135 nonfailing donors (NFDs) from six microarray datasets in the gene expression omnibus (GEO) database were included to evaluate the expression profiles of m<sup>7</sup>G regulators. Results revealed that 14 m<sup>7</sup>G regulators were differentially expressed in heart tissues from HF patients and NFDs. Furthermore, a five-gene m<sup>7</sup>G regulator diagnostic signature, NUDT16, NUDT4, CYFIP1, LARP1, and DCP2, which can easily distinguish HF patients and NFDs,"],"journal":["Clinical epigenetics"],"pubmed_title":["Identification of m<sup>7</sup>G regulator-mediated RNA methylation modification patterns and related immune microenvironment regulation characteristics in heart failure."],"pmcid":["PMC9926673"],"funding_grant_id":["19XD1423600","82170233"],"pubmed_authors":["Tu D","Ma C","Guo Z","Xu Q","Song X","Wu Y","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Identification of m<sup>7</sup>G regulator-mediated RNA methylation modification patterns and related immune microenvironment regulation characteristics in heart failure.","description":"<h4>Background</h4>N<sup>7</sup>-methylguanosine (m<sup>7</sup>G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment in heart failure (HF).<h4>Results</h4>One hundred twenty-four HF patients and 135 nonfailing donors (NFDs) from six microarray datasets in the gene expression omnibus (GEO) database were included to evaluate the expression profiles of m<sup>7</sup>G regulators. Results revealed that 14 m<sup>7</sup>G regulators were differentially expressed in heart tissues from HF patients and NFDs. Furthermore, a five-gene m<sup>7</sup>G regulator diagnostic signature, NUDT16, NUDT4, CYFIP1, LARP1, and DCP2, which can easily distinguish HF patients and NFDs,","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-19T03:51:47.237Z","creation":"2025-04-19T03:51:47.237Z"},"accession":"S-EPMC9926673","cross_references":{"pubmed":["36782329"],"doi":["10.1186/s13148-023-01439-3"]}}