biostudies-literatureUnknown18(2)Pong T<h4>Objective</h4>Analyze changes in frequency activity and structural organization that occur over time with persistent atrial fibrillation (AF).<h4>Background</h4>Little is known about the frequency characteristics of the epicardium during transition from paroxysmal to persistent AF. Accurate identification of areas of high dominant frequency (DF) is often hampered by limited spatial resolution. Improvements in electrode arrays provide high spatiotemporal resolution, allowing for characterization of the changes that occur during this transition.<h4>Methods</h4>AF was induced in adult Yorkshire swine by atrial tachypacing. DF mapping was performed using personalized mapping arrays. Histological analysis and late gadolinium enhanced magnetic resonance imaging were performed to determine stPloS onee0271846https://www.ebi.ac.uk/biostudies/studies/S-EPMC9928018biostudies-literatureHigh-resolution spatiotemporal changes in dominant frequency and structural organization during persistent atrial fibrillation.PMC9928018Lee AObafemi OTaylor CCarlton CAparicio-Valenzuela JPong TCyr KfalseHigh-resolution spatiotemporal changes in dominant frequency and structural organization during persistent atrial fibrillation.<h4>Objective</h4>Analyze changes in frequency activity and structural organization that occur over time with persistent atrial fibrillation (AF).<h4>Background</h4>Little is known about the frequency characteristics of the epicardium during transition from paroxysmal to persistent AF. Accurate identification of areas of high dominant frequency (DF) is often hampered by limited spatial resolution. Improvements in electrode arrays provide high spatiotemporal resolution, allowing for characterization of the changes that occur during this transition.<h4>Methods</h4>AF was induced in adult Yorkshire swine by atrial tachypacing. DF mapping was performed using personalized mapping arrays. Histological analysis and late gadolinium enhanced magnetic resonance imaging were performed to determine st2023-01-01T00:00:00Z20232025-04-22T19:56:16.209Z2025-04-06T02:58:13.126ZS-EPMC99280183678728710.1371/journal.pone.0271846