{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Jang MK"],"pubmed_abstract":["Patient monitoring is a cornerstone in clinical practice to define disease phenotypes and guide clinical management. Unfortunately, this is often reliant on invasive and/or less sensitive methods that do not provide deep phenotype assessments of disease state to guide treatment. This paper examined plasma cell-free DNA chromatin immunoprecipitation sequencing (cfChIP-seq) to define molecular gene sets in physiological and heart transplant patients taking immunosuppression medications. We show cfChIP-seq reliably detect gene signals that correlate with gene expression. In healthy controls and in heart transplant patients, cfChIP-seq reliably detected housekeeping genes. cfChIP-seq identified differential gene signals of the relevant immune and non-immune molecular pathways that were predomi"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.01.24.525414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9928031"],"repository":["biostudies-literature"],"pubmed_title":["Cell-free Chromatin Immunoprecipitation to detect molecular pathways in Physiological and Disease States."],"pmcid":["PMC9928031"],"pubmed_authors":["Markowitz TE","Agbor-Enoh S","Apalara Z","Andargie TE","Jang MK","Kuhn S"],"additional_accession":[]},"is_claimable":false,"name":"Cell-free Chromatin Immunoprecipitation to detect molecular pathways in Physiological and Disease States.","description":"Patient monitoring is a cornerstone in clinical practice to define disease phenotypes and guide clinical management. Unfortunately, this is often reliant on invasive and/or less sensitive methods that do not provide deep phenotype assessments of disease state to guide treatment. This paper examined plasma cell-free DNA chromatin immunoprecipitation sequencing (cfChIP-seq) to define molecular gene sets in physiological and heart transplant patients taking immunosuppression medications. We show cfChIP-seq reliably detect gene signals that correlate with gene expression. In healthy controls and in heart transplant patients, cfChIP-seq reliably detected housekeeping genes. cfChIP-seq identified differential gene signals of the relevant immune and non-immune molecular pathways that were predomi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-04-08T13:31:33.401Z","creation":"2025-04-05T11:23:54.502Z"},"accession":"S-EPMC9928031","cross_references":{"pubmed":["36789421"],"doi":["10.1101/2023.01.24.525414"]}}