{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muralidhar P"],"funding":["National Institutes of Health","NIGMS NIH HHS","National Science Foundation"],"pagination":["966-984"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9928167"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(5)"],"pubmed_abstract":["Genetic models of adaptation to a new environment have typically assumed that the alleles involved maintain a constant fitness dominance across the old and new environments. However, theories of dominance suggest that this should often not be the case. Instead, the alleles involved should frequently shift from recessive deleterious in the old environment to dominant beneficial in the new environment. Here, we study the consequences of these expected dominance shifts for the genetics of adaptation to a new environment. We find that dominance shifts increase the likelihood that adaptation occurs from standing variation, and that multiple alleles from the standing variation are involved (a soft selective sweep). Furthermore, we find that expected dominance shifts increase the haplotypic diver"],"journal":["Evolution; international journal of organic evolution"],"pubmed_title":["Dominance shifts increase the likelihood of soft selective sweeps."],"pmcid":["PMC9928167"],"funding_grant_id":["R35 GM136290","R01 GM108779","GM108779","GM13629"],"pubmed_authors":["Veller C","Muralidhar P"],"additional_accession":[]},"is_claimable":false,"name":"Dominance shifts increase the likelihood of soft selective sweeps.","description":"Genetic models of adaptation to a new environment have typically assumed that the alleles involved maintain a constant fitness dominance across the old and new environments. However, theories of dominance suggest that this should often not be the case. Instead, the alleles involved should frequently shift from recessive deleterious in the old environment to dominant beneficial in the new environment. Here, we study the consequences of these expected dominance shifts for the genetics of adaptation to a new environment. We find that dominance shifts increase the likelihood that adaptation occurs from standing variation, and that multiple alleles from the standing variation are involved (a soft selective sweep). Furthermore, we find that expected dominance shifts increase the haplotypic diver","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-04T09:18:47.821Z","creation":"2025-04-04T09:18:47.821Z"},"accession":"S-EPMC9928167","cross_references":{"pubmed":["35213740"],"doi":["10.1111/evo.14459"]}}