{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Palermo B"],"funding":["“Ricerca Corrente 2022” granted by the Italian Ministry of Health and partially supported by the Italian Association for Cancer Research"],"pagination":["2174721"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9928462"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["The impact of radiotherapy (RT) on immune cell status in prostate cancer (PCa) is only partially determined. The aim of this study was to assess the effect of different RT strategies on peripheral B, T, and Natural killer (NK) lymphocytes at precise longitudinal time-points in PCa. 18 patients treated with stereotactic body radiation therapy (SBRT) (40 Gy/3FRX), definitive moderate-hypofractionation (62 Gy/20FRX), or post-operative conventional-fractionation RT (66-69 Gy/30FRX) were prospectively evaluated for the immune cell profile in terms of immune cell composition, differentiation stage, cytokine production and inhibitory receptor (IR) expression. The immune-monitoring of the 18 patients revealed that RT affects the balance of systemic immune cells, with the main differences observed "],"journal":["Oncoimmunology"],"pubmed_title":["Stereotactic Ablative Radiation Therapy in 3 Fractions Induces a Favorable Systemic Immune Cell Profiling in Prostate Cancer Patients."],"pmcid":["PMC9928462"],"funding_grant_id":["PN AIRC IG 19822"],"pubmed_authors":["Sperduti I","Bottero M","Panetta M","Nistico P","Palermo B","Sanguineti G","Frisullo G","Cordone I","Masi S","Foddai ML","Faiella A"],"additional_accession":[]},"is_claimable":false,"name":"Stereotactic Ablative Radiation Therapy in 3 Fractions Induces a Favorable Systemic Immune Cell Profiling in Prostate Cancer Patients.","description":"The impact of radiotherapy (RT) on immune cell status in prostate cancer (PCa) is only partially determined. The aim of this study was to assess the effect of different RT strategies on peripheral B, T, and Natural killer (NK) lymphocytes at precise longitudinal time-points in PCa. 18 patients treated with stereotactic body radiation therapy (SBRT) (40 Gy/3FRX), definitive moderate-hypofractionation (62 Gy/20FRX), or post-operative conventional-fractionation RT (66-69 Gy/30FRX) were prospectively evaluated for the immune cell profile in terms of immune cell composition, differentiation stage, cytokine production and inhibitory receptor (IR) expression. The immune-monitoring of the 18 patients revealed that RT affects the balance of systemic immune cells, with the main differences observed ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-28T11:29:54.074Z","creation":"2025-02-19T03:27:17.612Z"},"accession":"S-EPMC9928462","cross_references":{"pubmed":["36798427"],"doi":["10.1080/2162402X.2023.2174721"]}}