{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ewing LE"],"funding":["National Institute of General Medical Sciences of the National Institutes of Health","Arkansas Center for Health Disparities via National Institute on Minority Health and Health Disparities","NIMHD NIH HHS","National Institute on Minority Health and Health Disparities","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["644-655"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9929030"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(4)"],"pubmed_abstract":["<h4>Purpose</h4>Nuclear weapons testing in the northern Marshall Islands between 1946 and 1958 resulted in ionizing radiation (IR) exposure of the thousands of Marshallese. Furthermore, numerous islands were contaminated by radioactive fallout. Significant increases in cancer and metabolic syndrome incidences have been reported among Marshallese, and potential for further increases looms due to the latency of radiation-induced health effects. The purpose of this study was to investigate the genetic and epigenetic effects of exposure to IR that could be associated with radiation-induced disease among the Northwest Arkansas (NWA) Marshallese.<h4>Materials and methods</h4>We performed analysis of chromosomal aberrations and DNA methylation based on residential and exposure history of NWA Mars"],"journal":["International journal of radiation biology"],"pubmed_title":["Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese."],"pmcid":["PMC9929030"],"funding_grant_id":["P20 GM109005","5U54MD002329-12","P20GM109005","U54 MD002329"],"pubmed_authors":["Landes RD","Riklon S","Stahr S","Skinner CM","Hauer-Jensen M","Ewing LE","Su J","Boerma M","Pathak R","McElfish PA","Koturbash I","Young SG","Binz R"],"additional_accession":[]},"is_claimable":false,"name":"Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese.","description":"<h4>Purpose</h4>Nuclear weapons testing in the northern Marshall Islands between 1946 and 1958 resulted in ionizing radiation (IR) exposure of the thousands of Marshallese. Furthermore, numerous islands were contaminated by radioactive fallout. Significant increases in cancer and metabolic syndrome incidences have been reported among Marshallese, and potential for further increases looms due to the latency of radiation-induced health effects. The purpose of this study was to investigate the genetic and epigenetic effects of exposure to IR that could be associated with radiation-induced disease among the Northwest Arkansas (NWA) Marshallese.<h4>Materials and methods</h4>We performed analysis of chromosomal aberrations and DNA methylation based on residential and exposure history of NWA Mars","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T03:01:09.935Z","creation":"2025-04-04T03:01:09.935Z"},"accession":"S-EPMC9929030","cross_references":{"pubmed":["35939319"],"doi":["10.1080/09553002.2022.2110319"]}}