{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Wang H"],"pubmed_abstract":["The main purpose of this study was to compare the antioxidant and anticancer activities of lycopene samples with different ratios of Z-isomers. Lycopene samples containing 5%, 30%, and 55% Z-isomers were successfully prepared by using thermal treatment combined with anti-solvent crystallization. The <i>in vitro</i> bio-accessibility of lycopene was estimated by the determination of partition factor (PF) and the results showed that lycopene with 55% Z-isomers possessed the highest bio-accessibility. Moreover, DPPH and ABTS assays suggested that the antioxidant activity of lycopene increased with the Z-isomers content from 5% to 55%. However, lycopene inhibited the survival of human hepatocellular carcinoma cells (HepG2) in a dose and time-dependent manner. The highest inhibition of HepG2 ce"],"journal":["Current research in food science"],"pagination":["100455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9929522"],"repository":["biostudies-literature"],"pubmed_title":["Antioxidant, anticancer activity and molecular docking study of lycopene with different ratios of Z-isomers."],"pmcid":["PMC9929522"],"pubmed_authors":["Zhang W","Hui A","Wu Z","Zhou A","Liu Q","Bian H","Lin Y","Wang H"],"additional_accession":[]},"is_claimable":false,"name":"Antioxidant, anticancer activity and molecular docking study of lycopene with different ratios of Z-isomers.","description":"The main purpose of this study was to compare the antioxidant and anticancer activities of lycopene samples with different ratios of Z-isomers. Lycopene samples containing 5%, 30%, and 55% Z-isomers were successfully prepared by using thermal treatment combined with anti-solvent crystallization. The <i>in vitro</i> bio-accessibility of lycopene was estimated by the determination of partition factor (PF) and the results showed that lycopene with 55% Z-isomers possessed the highest bio-accessibility. Moreover, DPPH and ABTS assays suggested that the antioxidant activity of lycopene increased with the Z-isomers content from 5% to 55%. However, lycopene inhibited the survival of human hepatocellular carcinoma cells (HepG2) in a dose and time-dependent manner. The highest inhibition of HepG2 ce","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-05-31T23:51:57.734Z","creation":"2024-11-12T12:57:54.765Z"},"accession":"S-EPMC9929522","cross_references":{"pubmed":["36815997"],"doi":["10.1016/j.crfs.2023.100455"]}}